For professionals working with specialized chemical compounds, a thorough understanding of their properties, handling requirements, and storage conditions is critical for safety and efficacy. 5-Bromo-2-chloro-3-fluoropyridine (CAS 831203-13-5) is a key intermediate in organic synthesis, and like many fine chemicals, it requires careful management. This article outlines the essential physical and chemical characteristics of this compound, alongside best practices for its safe handling and storage.

5-Bromo-2-chloro-3-fluoropyridine is typically supplied as a white to off-white crystalline powder. Its molecular formula is C5H2BrClFN, with a molecular weight of approximately 210.432 g/mol. Key physical properties reported include a density of around 1.8 g/cm³ and a boiling point of approximately 195.3 °C at 760 mmHg. Its flash point is around 71.9 °C, indicating moderate flammability. These properties are crucial for chemists and safety officers to consider during process design and risk assessment.

The chemical reactivity of 5-Bromo-2-chloro-3-fluoropyridine makes it an invaluable intermediate, particularly in the synthesis of pharmaceuticals and agrochemicals. The presence of three different halogen atoms on the pyridine ring allows for selective functionalization through various reactions, such as cross-coupling and nucleophilic substitution. Its high purity, generally u226598.0%, is essential for ensuring predictable reaction outcomes and minimizing the formation of unwanted byproducts in complex synthetic pathways. When you buy this compound, always verify the purity specifications from your supplier.

Safe handling practices are paramount when working with any chemical. When dealing with 5-Bromo-2-chloro-3-fluoropyridine, it is advisable to wear appropriate personal protective equipment (PPE), including gloves, eye protection, and protective clothing. Ensure adequate ventilation in the workspace, as inhalation of dust or vapors can be harmful. Specific hazard statements may include warnings related to skin and eye irritation, and potential respiratory irritation, underscoring the need for caution.

Proper storage is vital for maintaining the integrity and efficacy of 5-Bromo-2-chloro-3-fluoropyridine. The recommended storage condition is in a cool, well-ventilated place, often under an inert atmosphere like nitrogen or argon, and protected from light and moisture. Many suppliers package this compound in sealed drums to preserve its quality. Adhering to these storage guidelines, typically at temperatures between 2-8°C, helps prevent degradation and ensures the compound remains suitable for its intended synthetic applications. For bulk purchases, discussing optimal storage solutions with your manufacturer is a wise step.