For any chemist or materials scientist, a thorough understanding of a chemical's properties is fundamental to its successful application. Tert-Butyl 2-Bromo-2-Methylpropanoate (CAS 23877-12-5) is a prime example of an intermediate where detailed knowledge of its characteristics ensures optimal performance in synthesis and manufacturing. This compound, a reactive alkyl bromide ester, is widely sought after for its role in pharmaceuticals, polymer science, and organic synthesis.

Let's begin with its physical appearance. Tert-Butyl 2-Bromo-2-Methylpropanoate is typically described as a colorless to pale yellow liquid. This visual cue is important for initial quality assessment. Its density is also a key parameter, often cited around 1.25-1.30 g/cm³ at 20°C, indicating it is denser than water. The refractive index, usually within the range of 1.445-1.450 (n20D), serves as another important identifier and quality check.

Chemically, the compound's reactivity stems from the bromine atom, making it an excellent alkylating agent. This reactivity is precisely what makes it valuable in introducing tert-butyl ester groups and for applications like controlled radical polymerization (ATRP). Its molecular formula is C8H15BrO2, with a molecular weight of approximately 223.11 g/mol. Purity is a critical specification, with most suppliers offering it at ≥97% or higher purity, often verified by Gas Chromatography (GC). This high purity is non-negotiable for its demanding applications in pharmaceutical intermediates.

Solubility is another important property. Tert-Butyl 2-Bromo-2-Methylpropanoate is generally soluble in common organic solvents such as tetrahydrofuran (THF) and dichloromethane (DCM), but it is insoluble in water. This characteristic guides its use in various reaction media and purification processes. For example, when planning reactions or purification steps, knowing it won't readily dissolve in water is crucial.

Regarding handling and storage, the compound's reactive nature necessitates careful attention. It is often classified with hazard codes such as H314 (Causes severe skin burns and eye damage) and H335 (May cause respiratory irritation). Therefore, appropriate personal protective equipment (PPE) and handling in a well-ventilated area are essential. Long-term storage typically requires conditions of 2-8°C, often under an inert atmosphere like nitrogen (N2) or argon (Ar), to prevent degradation and maintain its reactivity.

For those looking to buy this intermediate, understanding these properties helps in making informed decisions. When sourcing, one might search for 'chemical intermediate supplier' or 'reactive organic compound manufacturer'. Inquiries should focus on obtaining detailed specifications and ensuring the supplier adheres to safety and quality standards. For example, knowing the boiling point, which is around 70-72°C at 10 mmHg, can be relevant for process design.

In essence, Tert-Butyl 2-Bromo-2-Methylpropanoate is a powerful chemical tool. Its well-defined physical and chemical properties make it a reliable component in advanced chemical synthesis. Researchers and manufacturers who understand and respect these characteristics can leverage this intermediate for groundbreaking innovations, ensuring efficiency and safety in their operations.