In the intricate world of chemical synthesis, specific intermediates stand out for their unique contributions to creating complex molecules. 3-(tert-Butyldimethylsilyloxy)glutaric anhydride, identified by CAS number 91424-40-7, is one such compound that has garnered significant attention, particularly within the pharmaceutical sector. Understanding its physical and chemical properties, along with its diverse applications, is crucial for R&D scientists, chemists, and procurement specialists looking to source this valuable intermediate.

Chemical Profile: What is 3-(tert-Butyldimethylsilyloxy)glutaric Anhydride?

This chemical compound is characterized by its molecular formula C11H20O4Si and a molecular weight of 244.36 g/mol. Its structure features a glutaric anhydride core with a tert-butyldimethylsilyl (TBS) protecting group attached to the hydroxyl functionality at the 3-position. This specific molecular architecture provides several key attributes:

  • Appearance: Typically supplied as a white powder, its physical form is conducive to easy handling and precise measurement in laboratory settings.
  • Reactivity: The anhydride group is highly reactive and readily participates in nucleophilic attack, making it ideal for forming ester, amide, and other carbonyl derivatives.
  • Protection: The tert-butyldimethylsilyl (TBS) group serves as a protective group for the hydroxyl functionality. This protection is stable under various reaction conditions but can be selectively removed when needed, allowing for controlled synthetic pathways.
  • Stability: While sensitive to moisture, under proper storage conditions (cool, dry, and tightly closed containers), it maintains its integrity for synthesis.

Key Applications in Synthesis

The primary driver for the demand for 3-(tert-Butyldimethylsilyloxy)glutaric anhydride stems from its critical role as a pharmaceutical intermediate. It is a vital component in the synthesis of statins, a class of drugs that effectively manage hypercholesterolemia. Specifically, it is extensively used in the manufacturing of Rosuvastatin, a blockbuster drug for lowering cholesterol.

Beyond pharmaceutical applications, this anhydride is a versatile building block for general organic synthesis. Researchers leverage its structure for:

  • Chiral Synthesis: It can be employed in stereoselective reactions, contributing to the synthesis of enantiomerically pure compounds.
  • Developing Novel Molecules: Its reactive sites allow for functional group interconversions and the creation of new chemical entities for various research purposes.
  • Advanced Material Science: Potential applications exist in the development of specialized polymers and materials where its unique structure can impart desired properties.

Procurement Considerations for B2B Buyers

When looking to purchase 3-(tert-Butyldimethylsilyloxy)glutaric anhydride, B2B buyers should prioritize suppliers who can guarantee high purity (e.g., ≥98.0%) and consistent quality. Establishing a relationship with a reliable manufacturer or supplier, especially one with a strong presence in China, can secure competitive pricing and ensure a stable supply chain. Procurement managers often request quotes and samples to verify product specifications and supplier reliability before committing to larger purchase orders.

The ability to buy 3-(tert-Butyldimethylsilyloxy)glutaric anhydride from a trusted source is fundamental to the success of any synthesis project. Whether for the production of life-saving medications or for cutting-edge research, ensuring the quality and availability of this intermediate is key.

Conclusion

3-(tert-Butyldimethylsilyloxy)glutaric anhydride is more than just a chemical intermediate; it's an enabler of innovation in the pharmaceutical and chemical industries. Its distinct properties and critical applications, especially in statin synthesis, underscore its importance. For companies seeking this compound, focusing on quality, supplier reliability, and competitive pricing will pave the way for successful procurement and synthesis outcomes.