For professionals in the chemical and pharmaceutical industries, a deep understanding of the intermediates they use is crucial. 2-Hydroxy-5-methylpyridine (CAS 1003-68-5) is a prime example of such a vital compound. This heterocyclic organic molecule, often referred to as 5-Methyl-2-pyridinol, serves as a critical building block in numerous synthesis pathways. Ensuring its quality, particularly its purity, and understanding its manufacturing processes are key considerations for any B2B buyer looking to purchase this chemical.

The synthesis of 2-Hydroxy-5-methylpyridine involves sophisticated chemical reactions. One common route described in chemical literature involves the hydrogenation of 3-cyano-6-hydroxypyridine. Another significant method begins with 2-bromo-5-methylpyridine, which is subjected to a reaction involving potassium tert-butylate followed by treatment with formic acid to yield the desired product. These synthesis pathways, when optimized by chemical manufacturers, aim for high yields and minimal by-products, ensuring that the resulting 2-Hydroxy-5-methylpyridine meets stringent quality standards.

Purity is a paramount concern for users of 2-Hydroxy-5-methylpyridine, especially in pharmaceutical and advanced material applications. Typically, manufacturers offer this compound with purity levels of 97% or higher, as confirmed by analytical techniques like High-Performance Liquid Chromatography (HPLC) or Gas Chromatography (GC). Buyers should always request and review Certificates of Analysis (CoA) to verify the purity and identify any residual impurities. For instance, its presence as an impurity in certain drug substances, like Pirfenidone, underscores the importance of precise synthesis and quality control.

When considering purchasing 2-Hydroxy-5-methylpyridine, understanding its physical properties is also beneficial. It typically appears as a white to pale yellow solid, with a melting point in the range of 183-187 °C. Its solubility in common organic solvents like DMSO, ethanol, and methanol is noted as slight, which can influence reaction conditions in synthesis applications. These properties, detailed by manufacturers and suppliers, help formulators plan their experimental procedures.

For businesses looking to buy 2-Hydroxy-5-methylpyridine, engaging with reliable manufacturers and suppliers is essential. Companies specializing in fine chemical intermediates, particularly those in China, are often prominent suppliers. They offer competitive pricing and can provide the necessary technical documentation and support. When requesting a quote, specifying the required purity, quantity, and desired packaging will help ensure an accurate and efficient procurement process. Bulk purchases for industrial applications often come with advantageous pricing structures.

In conclusion, 2-Hydroxy-5-methylpyridine (CAS 1003-68-5) is a vital chemical intermediate whose value is intrinsically linked to its synthesis and purity. Understanding its production routes and the importance of quality control allows buyers to make informed decisions. As a cornerstone for advancements in pharmaceuticals and organic synthesis, securing a consistent supply of high-quality 2-Hydroxy-5-methylpyridine from trusted manufacturers remains a strategic priority for many industries.