The pyrazolopyridine scaffold represents a significant class of heterocyclic compounds widely recognized for their diverse biological activities and applications in medicinal chemistry. Among these, 5-Fluoro-1H-Pyrazolo[3,4-b]Pyridin-3-Amine, identified by its CAS number 1034667-22-5, is a particularly important derivative. NINGBO INNO PHARMCHEM CO.,LTD. is at the forefront of supplying such high-value chemical compounds that enable cutting-edge research and development.

The chemical structure of 5-Fluoro-1H-Pyrazolo[3,4-b]Pyridin-3-Amine is characterized by the fusion of a pyrazole ring and a pyridine ring, further functionalized with a fluorine atom at the 5-position and an amine group at the 3-position. This unique arrangement confers specific electronic and steric properties, making it a sought-after intermediate for synthesizing more complex molecules. The fluorine substituent, in particular, can enhance lipophilicity and metabolic stability, attributes that are highly desirable in drug candidates. Understanding the synthesis of this compound, as supported by NINGBO INNO PHARMCHEM CO.,LTD., is crucial for its effective utilization.

Researchers often utilize 5-Fluoro-1H-Pyrazolo[3,4-b]Pyridin-3-Amine as a starting material for creating a wide array of novel compounds. Its amine group provides a convenient handle for various coupling reactions, while the pyrazolopyridine core can be further modified to fine-tune biological activity. This versatility makes it invaluable in the quest for new therapeutic agents, from anti-cancer drugs to treatments for cardiovascular diseases, building upon the foundation of pyrazolopyridine chemistry.

The specific application in Vericiguat intermediate synthesis highlights the compound's practical importance. Vericiguat, a stimulator of soluble guanylate cyclase (sGC), is used to treat heart failure, and intermediates like 5-Fluoro-1H-Pyrazolo[3,4-b]Pyridin-3-Amine are critical for its efficient and scalable production. NINGBO INNO PHARMCHEM CO.,LTD. ensures that the supply chain for such essential components remains robust, supporting the pharmaceutical industry's efforts to bring life-saving medications to market.

In summary, the study and application of pyrazolopyridine chemistry, exemplified by 5-Fluoro-1H-Pyrazolo[3,4-b]Pyridin-3-Amine (CAS 1034667-22-5), are essential for advancing medicinal chemistry. NINGBO INNO PHARMCHEM CO.,LTD. plays a vital role in this ecosystem by providing researchers with the high-quality chemical building blocks they need to innovate and discover new therapies.