(R)-N-Boc-3-hydroxyadamantylglycine, identified by its CAS number 1334321-39-9, is a compound of significant interest within the pharmaceutical industry. As a chiral intermediate, its precise molecular structure and purity are critical for its application in the synthesis of complex Active Pharmaceutical Ingredients (APIs). Understanding its properties and sourcing reliably are key for R&D scientists and procurement specialists.

Chemically, (R)-N-Boc-3-hydroxyadamantylglycine is a Boc-protected amino acid derivative featuring an adamantane core. The 'Boc' group (tert-butoxycarbonyl) serves as a common protecting group in organic synthesis, allowing for selective reactions. The 'R' designation indicates a specific stereoisomer, highlighting its chiral nature, which is often crucial for biological activity in pharmaceutical compounds.

One of its most prominent applications is as a building block in the synthesis of Saxagliptin. Saxagliptin is a potent and selective reversible inhibitor of dipeptidyl peptidase-4 (DPP-4), widely used in the treatment of type 2 diabetes. The efficient and enantiomerically pure synthesis of Saxagliptin relies heavily on the availability of high-quality intermediates like (R)-N-Boc-3-hydroxyadamantylglycine. Pharmaceutical companies looking to buy this compound for such applications often seek out specialized manufacturers who can guarantee consistent enantiomeric excess.

Furthermore, (R)-N-Boc-3-hydroxyadamantylglycine is also identified as an impurity in the Saxagliptin manufacturing process. This dual role means it is essential both as a synthetic precursor and as a reference standard for quality control. Reliable suppliers who can provide this compound in various grades and quantities are indispensable for pharmaceutical R&D and manufacturing operations.

When considering purchase of (R)-N-Boc-3-hydroxyadamantylglycine, potential buyers should pay close attention to the specifications provided by the manufacturer. Key attributes to verify include melting point (typically >280°C with decomposition), solubility in common organic solvents, and most importantly, the enantiomeric purity. Working with a reputable supplier in China can offer access to competitive pricing and a stable supply chain.

In summary, (R)-N-Boc-3-hydroxyadamantylglycine is a valuable chiral intermediate with direct relevance to important therapeutic agents. Its role in Saxagliptin synthesis and as a quality control standard underscores the need for careful sourcing from experienced and quality-conscious chemical manufacturers and suppliers.