For professionals in the pharmaceutical and fine chemical industries, a deep understanding of key intermediates is crucial for successful research, development, and manufacturing. (S)-tert-Butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate, known by its CAS number 102123-74-0, is one such compound that warrants close attention. This article delves into its chemical identity, physical properties, primary applications, and considerations for sourcing this valuable material.

Chemically, (S)-tert-Butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate is a complex organic molecule featuring a chiral center, a ketone group, a chlorine atom, and a tert-butoxycarbonyl (Boc) protecting group attached to an amino moiety. Its molecular formula is C15H20ClNO3, with a molecular weight of approximately 297.78 g/mol. As noted in its specifications, it typically presents as a White crystalline powder, a physical form that facilitates accurate weighing and handling in laboratory and industrial settings. The assay value of ≥98.0% signifies its high purity, which is a critical requirement for its use in sophisticated chemical syntheses.

The primary and most significant application of (S)-tert-Butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate lies in its role as a key intermediate in the synthesis of Darunavir. Darunavir is a potent protease inhibitor used in the treatment of HIV infection. The specific chiral configuration of this intermediate is essential for the stereospecific synthesis of Darunavir, ensuring the correct three-dimensional structure required for its biological activity. Researchers and formulators looking to buy this compound for drug development programs can rely on its established utility in this critical pathway.

When considering the purchase of CAS 102123-74-0, it is important for R&D scientists to evaluate potential suppliers based on their ability to provide consistent quality and reliable supply. Manufacturers offering this intermediate should ideally have robust quality control measures in place. Furthermore, understanding the available packaging options, from research quantities to bulk drums, is essential for planning laboratory experiments and production campaigns. Inquiring about the price of this pharmaceutical intermediate from various suppliers can help procurement teams secure the best value. For those seeking a domestic manufacturer in China, exploring options that offer both competitive pricing and a strong commitment to quality is a prudent strategy.

In summary, (S)-tert-Butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate (CAS 102123-74-0) is a high-purity, white crystalline powder that serves as a cornerstone intermediate in the synthesis of Darunavir and other complex organic molecules. Its precise chemical structure and chirality make it indispensable for specific pharmaceutical applications. For any scientist or procurement specialist needing this compound, thorough supplier evaluation focusing on purity, consistency, and availability is key.