In the complex world of pharmaceutical manufacturing, the quality and consistency of chemical intermediates are foundational to the success of the final drug product. Procurement managers and R&D scientists must possess a thorough understanding of chemical specifications to make informed purchasing decisions. This article focuses on key attributes to consider when buying intermediates such as 6-Acetoxy-4-chloro-7-methoxyquinazoline (CAS: 230955-75-6).

The Critical Role of CAS Numbers and Chemical Names
Every chemical compound is uniquely identified by its Chemical Abstracts Service (CAS) Registry Number. For 6-Acetoxy-4-chloro-7-methoxyquinazoline, the CAS number is 230955-75-6. This number is crucial for unambiguous identification, especially in global trade and regulatory compliance. Beyond the CAS number, understanding synonyms and alternative chemical names, such as 4-Chloro-6-acetoxy-7-methoxyquinazoline or Gefitinib Intermediate V, ensures clarity and avoids misidentification. Always confirm that the CAS number and chemical name match your exact requirement.

Purity: The Cornerstone of Pharmaceutical Intermediates
Purity is arguably the most critical specification for any pharmaceutical intermediate. For 6-Acetoxy-4-chloro-7-methoxyquinazoline, typical purity requirements often exceed 97%, with many applications demanding 98% or even 99% purity. The primary analytical method for determining purity is High-Performance Liquid Chromatography (HPLC). When you request a Certificate of Analysis (CoA) from a manufacturer or supplier, ensure it includes HPLC chromatograms or purity values. Higher purity minimizes the risk of unwanted side reactions during synthesis and reduces the burden of downstream purification, ultimately impacting the final API's quality.

Physical Properties: Appearance and Form
The physical appearance of a chemical intermediate provides initial clues about its quality. 6-Acetoxy-4-chloro-7-methoxyquinazoline is typically described as an 'Off-white to light yellow solid.' Deviations from this description could indicate degradation, contamination, or improper storage. The physical form (e.g., powder, crystalline solid) can also influence handling, dissolution rates, and reactivity. Suppliers should clearly state these properties on their documentation.

Molecular Formula and Weight
Knowing the molecular formula (C11H9ClN2O3) and molecular weight (252.65 g/mol) is fundamental for stoichiometric calculations in synthesis. These values are derived from the chemical structure and are standard parameters provided by manufacturers. They are essential for accurate dosing in chemical reactions and for analytical verification.

Storage Conditions and Stability
Proper storage is vital for maintaining the integrity of chemical intermediates. For 6-Acetoxy-4-chloro-7-methoxyquinazoline, recommended storage often involves cool, dry conditions, sometimes under an inert atmosphere (e.g., nitrogen or argon) at specified temperatures (e.g., 2-8°C). Understanding these requirements helps ensure the compound's stability from the supplier's facility to your laboratory or production site. Always check the supplier's recommended storage conditions and expiry dates.

Why Partner with a Reputable Manufacturer?
Choosing a supplier that consistently provides detailed and accurate specifications is crucial. Companies like ours, as dedicated manufacturers, invest heavily in quality control systems and analytical instrumentation to guarantee that our products, including 6-Acetoxy-4-chloro-7-methoxyquinazoline, meet the highest standards. We ensure that every batch is accompanied by comprehensive documentation, giving you the confidence to buy and use our materials in your critical applications. Contact us to learn more about our product specifications and how we can support your pharmaceutical development needs.