For professionals in organic synthesis and medicinal chemistry, a deep understanding of key building blocks is essential for successful product development. Fmoc-D-Pen(Trt)-OH is one such compound, critical for the synthesis of peptides and peptidomimetics. Its unique structural features, protected thiol and Fmoc-protected amine, make it a versatile reagent in various synthetic strategies. NINGBO INNO PHARMCHEM CO.,LTD., a prominent manufacturer of fine chemicals in China, provides high-quality Fmoc-D-Pen(Trt)-OH (CAS: 201532-01-6) and offers insights into its synthesis and applications.

Fmoc-D-Pen(Trt)-OH, formally known as N-Fmoc-S-trityl-D-penicillamine, is derived from D-penicillamine. The synthesis typically involves the sequential protection of the amine and thiol groups. The alpha-amino group is protected with the Fmoc moiety using Fmoc-Cl or Fmoc-OSu under basic conditions. Subsequently, the thiol group is protected with a trityl group, commonly by reacting with triphenylmethyl chloride (trityl chloride) in the presence of a base. The choice of protection strategy, particularly the trityl group for the thiol, is significant because it is stable under the conditions used for Fmoc deprotection but can be readily removed under acidic conditions, often alongside other acid-labile side-chain protecting groups. This orthogonal protection scheme is a hallmark of modern peptide synthesis. When looking to buy Fmoc-D-Pen(Trt)-OH, it is crucial to understand these synthetic nuances and source from a manufacturer with robust quality control.

The primary application of Fmoc-D-Pen(Trt)-OH is in solid-phase peptide synthesis (SPPS), particularly within the Fmoc/tBu strategy. It is used to introduce D-penicillamine residues into peptide sequences. This is often done when disulfide bonds are required to stabilize peptide structure, or when the unique steric and electronic properties of penicillamine are desired for modulating peptide activity. The ability to precisely control the formation of disulfide bonds, by selectively deprotecting the thiol group of the penicillamine residue, is invaluable for researchers developing complex peptides for therapeutic or diagnostic purposes. Understanding the Fmoc-D-Pen(Trt)-OH price in relation to its synthetic utility is important for project planning.

NINGBO INNO PHARMCHEM CO.,LTD. serves as a reliable supplier of Fmoc-D-Pen(Trt)-OH, ensuring that researchers and chemical companies have access to this vital reagent. As a dedicated manufacturer, we meticulously control our synthesis processes to guarantee the purity and consistency of our products, which are essential for reproducible results in complex organic synthesis. Our extensive experience in producing Fmoc-amino acids makes us a trusted partner for your chemical sourcing needs.

For laboratories and pharmaceutical companies looking to purchase Fmoc-D-Pen(Trt)-OH, NINGBO INNO PHARMCHEM CO.,LTD. offers a combination of quality, competitive pricing, and reliable supply. We are committed to supporting scientific innovation by providing access to the highest grade chemical intermediates. We encourage you to reach out to us for quotations and to discuss how we can fulfill your specific requirements for Fmoc-D-Pen(Trt)-OH and other essential synthetic building blocks.

In summary, Fmoc-D-Pen(Trt)-OH is a key intermediate in peptide synthesis, owing to its strategic protection of amine and thiol groups. NINGBO INNO PHARMCHEM CO.,LTD. is your trusted manufacturer and supplier, ensuring the quality and availability of this critical compound for your synthetic chemistry needs.