For professionals in the chemical and pharmaceutical industries, a deep understanding of key intermediates is crucial for innovation and efficient production. 5-(4-Bromophenyl)-4,6-dichloropyrimidine, identified by CAS number 146533-41-7, is a prime example of such a compound. Its primary significance lies in its role as an intermediate in the synthesis of Macitentan, a critical pharmaceutical agent used in treating pulmonary arterial hypertension.

The synthesis of 5-(4-Bromophenyl)-4,6-dichloropyrimidine typically involves transforming 5-(4-Bromophenyl) pyrimidine-4, 6-diol using reagents like phosphorus oxychloride (POCl3). This process, often carried out under reflux conditions followed by neutralization and isolation, yields the desired white powder. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. refine these synthesis routes to ensure high purity (often exceeding 98%) and efficient production, making the compound readily available for purchase by R&D scientists and procurement managers.

Beyond its well-established use in Macitentan synthesis, the unique structure of 5-(4-Bromophenyl)-4,6-dichloropyrimidine makes it a versatile building block in broader organic synthesis and medicinal chemistry. Researchers can explore its reactivity for developing new heterocyclic compounds, potential agrochemicals, or advanced materials. Its dichloropyrimidine moiety allows for nucleophilic substitution reactions, while the bromophenyl group can be utilized in cross-coupling reactions, opening up a wide array of derivatization possibilities.

When sourcing this compound, it is essential to look for a reliable supplier that guarantees quality and consistency. NINGBO INNO PHARMCHEM CO.,LTD., as a leading manufacturer and supplier in China, ensures that our 5-(4-Bromophenyl)-4,6-dichloropyrimidine meets stringent specifications. We provide comprehensive product details, including appearance (white powder), melting point (98-102°C), and recommended storage conditions (under inert gas at 2-8°C).

For those looking to buy this critical intermediate, understanding its synthesis and potential applications allows for more informed procurement decisions. Whether your focus is on pharmaceutical manufacturing, academic research, or custom synthesis projects, NINGBO INNO PHARMCHEM CO.,LTD. is your go-to source for high-quality 5-(4-Bromophenyl)-4,6-dichloropyrimidine. Contact us to request a quote and explore how we can support your chemical needs.