For chemical engineers, R&D scientists, and procurement professionals, understanding the synthesis and properties of key industrial chemicals is fundamental. 2-tert-Butyl-4,6-dimethylphenol (CAS 1879-09-0) is a compound with significant industrial utility, known for its roles as an antioxidant, polymerization inhibitor, and pharmaceutical intermediate. This article explores its synthesis pathways and core properties.

The primary industrial synthesis method for 2-tert-Butyl-4,6-dimethylphenol involves the Friedel-Crafts alkylation of 2,4-dimethylphenol with isobutylene. This reaction typically occurs in the presence of an acid catalyst. The process requires careful control of reaction conditions, such as temperature and reactant ratios, to maximize the yield of the desired product and minimize by-products. Selectivity for the 6-position alkylation is generally high due to steric factors and electronic effects of the hydroxyl and methyl groups on the phenolic ring.

Key properties of 2-tert-Butyl-4,6-dimethylphenol include its appearance as a clear, colorless to straw-colored liquid, with a melting point around 20-24°C, meaning it can exist as a solid or liquid at ambient temperatures depending on the specific conditions. It has a molecular weight of 178.27 and a high boiling point of approximately 249°C. Its solubility is limited in water but good in organic solvents.

Industrially, it serves as a potent antioxidant, particularly effective at high temperatures, making it ideal for aviation fuels. It also acts as an acrylic acid polymerization inhibitor, preventing premature and potentially hazardous polymerization. As a pharmaceutical intermediate, its purity and consistent quality are paramount, which is why manufacturers like us maintain strict quality control over our production. We ensure our products have an assay of ≥98.5%.

For those looking to buy this versatile chemical, understanding its synthesis and properties allows for informed purchasing decisions. As a manufacturer and supplier based in China, we offer competitive pricing and reliable supply for 2-tert-Butyl-4,6-dimethylphenol. We are committed to supporting your research and industrial needs. Contact us to request a quote and learn more about our product specifications and bulk purchasing options.