1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is a macrocyclic compound that has revolutionized several fields within medical science, primarily due to its exceptional metal-chelating capabilities. This molecule, with its characteristic 12-membered tetraaza ring, is synthesized through complex organic chemical processes to achieve the high purity required for its advanced applications. As a dedicated manufacturer and supplier of DOTA in China, we focus on delivering a product that adheres to stringent quality standards, essential for its use in critical biomedical applications.

The chemical structure of DOTA features four nitrogen atoms within a stable ring, each substituted with an acetic acid group. This arrangement creates a cage-like structure that effectively encapsulates metal ions, forming highly stable complexes. The resulting chelation is significantly more robust than linear chelators, such as DTPA, making DOTA the preferred choice for applications demanding long-term stability and resistance to transmetalation. This enhanced stability is particularly important for in vivo applications, where the premature release of metal ions, such as Gadolinium or radioisotopes, could lead to toxicity. For researchers and formulators looking to buy DOTA, understanding these properties highlights why sourcing from a quality manufacturer is crucial for successful outcomes in MRI contrast agents and radiopharmaceuticals.

The primary application driving the demand for DOTA is its use in medical imaging. In MRI, DOTA-based Gadolinium complexes are widely used as contrast agents. These agents improve the visibility of tissues and lesions by altering the relaxation times of water protons in their vicinity. The stability of the DOTA-Gd complex ensures that the Gadolinium remains safely bound, preventing potential adverse effects. Beyond MRI, DOTA is indispensable in nuclear medicine for creating diagnostic imaging agents and therapeutic radiopharmaceuticals. By chelating radioisotopes like Gallium-68, it allows for PET imaging of various diseases, while isotopes like Lutetium-177 enable targeted radiotherapy. Our role as a DOTA supplier involves providing this foundational material with a purity of ≥98.0% to support these life-saving technologies.

The synthesis of DOTA itself is a multi-step process requiring careful control over reaction conditions to achieve high yields and purity. As a chemical manufacturer, we have optimized these processes to offer DOTA at a competitive DOTA price, making it accessible for widespread use. Whether you are a pharmaceutical company developing new diagnostic tools or a research institution exploring novel therapeutic strategies, our capabilities as a DOTA supplier in China ensure a reliable and high-quality source for your needs. We invite you to inquire about our product specifications and discuss how we can support your projects requiring this vital chelating agent.