Methyl 6-bromonicotinate (CAS 26218-78-0) is a cornerstone compound in modern organic chemistry, serving as a critical intermediate for numerous synthesis pathways. Its structure, a methyl ester of 6-bromonicotinic acid, lends itself to a wide range of applications, particularly in the pharmaceutical and agrochemical sectors. For R&D scientists and procurement managers, a thorough understanding of this chemical's synthesis and application is key to making informed sourcing decisions. This guide offers insights from a chemical manufacturer's perspective on why sourcing high-quality Methyl 6-bromonicotinate is vital.

The synthesis of Methyl 6-bromonicotinate typically involves the esterification of 6-bromonicotinic acid. Procedures often utilize reagents like methanol in the presence of an acid catalyst, or involve converting the acid to its acid chloride followed by reaction with methanol. Achieving high purity, commonly measured by HPLC (e.g., ≥97%), is essential as impurities can significantly impact downstream reactions and the quality of the final product. The compound presents as a white to almost white solid, with a melting point generally in the range of 106-110°C, providing clear physical identifiers for quality control.

The utility of Methyl 6-bromonicotinate is vast, primarily driven by its reactive bromine atom. In pharmaceutical synthesis, it is extensively used as a precursor for creating complex heterocyclic structures that form the backbone of many drug molecules. These include compounds designed to treat neurological disorders, inflammation, and various other conditions. The ability to efficiently introduce diverse functionalities via cross-coupling reactions makes it an indispensable tool for medicinal chemists aiming to discover and develop novel therapeutics. To support these efforts, researchers need to buy consistently pure material.

In the agrochemical industry, Methyl 6-bromonicotinate is employed in the synthesis of active ingredients for pesticides, herbicides, and other crop protection agents. These compounds are critical for modern agriculture, helping to ensure food security by protecting crops from pests and diseases. The development of more effective and environmentally friendly agrochemicals relies on access to high-quality intermediates like this. Procurement specialists often seek competitive pricing from dedicated suppliers to manage project budgets effectively.

NINGBO INNO PHARMCHEM CO.,LTD. is a leading manufacturer and supplier in China of Methyl 6-bromonicotinate. We are committed to delivering products that meet rigorous quality standards, ensuring lot-to-lot consistency, and offering competitive pricing for bulk orders. We invite all professionals looking to purchase this essential intermediate to request a quote from us. Our goal is to support your scientific endeavors by providing reliable access to high-quality chemical building blocks.