For research and development scientists in the pharmaceutical industry, a deep understanding of the synthesis pathways for critical intermediates is invaluable. 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyrimidin-7(8H)-one (CAS 1013916-37-4) is a prime example, serving as a pivotal precursor in the production of Palbociclib, a significant therapeutic agent for breast cancer. This article provides a chemical perspective on the synthesis of this intermediate, discussing common routes and considerations for those looking to purchase it for their research or manufacturing needs.

The synthesis of 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyrimidin-7(8H)-one typically involves multistep organic reactions. One common approach, as suggested by literature and patent disclosures, involves cyclization and functionalization reactions starting from simpler pyrimidine and pyridine derivatives. Key steps often include amination, condensation, and halogenation reactions, employing specific reagents and catalysts to achieve the desired molecular structure. The exact synthetic route can vary depending on the manufacturer and their proprietary processes, aiming for optimal yield, purity, and cost-effectiveness.

Scientists aiming to buy Palbociclib intermediates like CAS 1013916-37-4 should be aware of the technical challenges associated with its production. Achieving high purity (≥98%) often requires meticulous purification techniques, such as chromatography or recrystallization, to remove byproducts and unreacted starting materials. The use of specialized catalysts, like palladium compounds in certain coupling reactions, also requires careful handling and process optimization.

For R&D purposes, understanding the synthesis helps in anticipating potential impurities and designing analytical methods for quality control. When sourcing this intermediate, consider suppliers who provide detailed synthesis information or highlight their process development expertise. Manufacturers in China are often at the forefront of optimizing these synthetic routes, making them a valuable resource for procuring this compound.

In conclusion, the synthesis of 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyrimidin-7(8H)-one is a sophisticated chemical undertaking. R&D scientists looking to purchase this essential Palbociclib intermediate should seek suppliers with proven expertise in complex organic synthesis and stringent quality control. A thorough understanding of the chemistry involved ensures the successful application of this vital compound in pharmaceutical development.

For those requiring detailed synthesis information or seeking to purchase CAS 1013916-37-4, consulting with experienced pharmaceutical intermediate manufacturers is highly recommended.