For professionals in the chemical industry, a thorough understanding of a compound's synthesis and properties is fundamental to its effective utilization. 2-Chloro-5-nitrobenzoic Acid (CAS 2516-96-3) is a prime example of a versatile intermediate whose value is directly linked to its carefully managed production and predictable characteristics.

The primary industrial synthesis route for 2-Chloro-5-nitrobenzoic Acid involves the nitration of ortho-chlorobenzoic acid. This process typically uses a mixture of concentrated sulfuric acid and nitric acid. Careful control of reaction temperature (often between 30-40°C) and reactant ratios is critical to maximize the yield of the desired 5-nitro isomer and minimize the formation of the less useful 2-chloro-3-nitrobenzoic acid. Manufacturers often employ advanced techniques to optimize this regioselective nitration, ensuring high purity of the final product.

Alternative synthesis pathways exist, sometimes utilizing different starting materials or solvents like dichloromethane to improve handling or reduce by-product formation. These methods are often detailed in patents and scientific literature, reflecting ongoing efforts to refine production efficiency and sustainability. When considering purchasing this chemical, looking at the details provided by a reputable chemical manufacturer can offer insights into their process and quality assurance.

Key physicochemical properties of 2-Chloro-5-nitrobenzoic Acid include its appearance as a yellow crystalline solid, its solubility profile (generally soluble in organic solvents and less so in water), and its melting point, typically around 165-168°C. These properties are vital for formulators and researchers when designing reaction conditions or formulating final products.

For those seeking to buy 2-chloro-5-nitrobenzoic acid, understanding these synthesis and property details helps in selecting the right grade and supplier. Companies that provide comprehensive technical data, including detailed specifications and synthesis information, are often preferred. Furthermore, inquiring about the price of 2-chloro-5-nitrobenzoic acid should always be accompanied by a review of the product's specifications to ensure it meets the required quality standards for your intended application.

As a critical intermediate, the efficient and quality-controlled production of 2-Chloro-5-nitrobenzoic Acid is essential. Its well-defined synthesis and predictable properties make it a reliable choice for a wide range of applications in organic chemistry, drug discovery, and agrochemical development. Partnering with knowledgeable chemical suppliers who can provide these essential intermediates ensures that your projects can proceed with confidence and efficiency.