For scientists and engineers engaged in organic synthesis, a deep understanding of chemical intermediates is crucial for successful project outcomes. 4-(Trifluoromethoxy)aniline (CAS 461-82-5) is a compound of significant interest due to its unique structural features and broad applicability in pharmaceuticals, agrochemicals, and material science. This article explores its synthesis and key chemical properties.

The synthesis of 4-(Trifluoromethoxy)aniline typically involves advanced fluorination techniques. While specific proprietary methods exist among manufacturers, common approaches may include the trifluoromethoxylation of aniline precursors or related aromatic compounds. Reputable suppliers often detail their commitment to high-purity synthesis, aiming for product specifications of ≥99.0% purity via Gas Chromatography (GC). The resulting product is generally described as a pale yellow liquid, possessing a molecular formula of C7H6F3NO and a molecular weight of 177.12 g/mol. Key physical properties like boiling point (around 73-75°C at atmospheric pressure, or 83°C/20.3 mmHg) and refractive index (n20D ~1.463) are important considerations for formulators and researchers when they buy this intermediate.

The trifluoromethoxy group (-OCF3) is the defining characteristic of this molecule, imparting increased lipophilicity and metabolic stability compared to non-fluorinated analogs. This makes it an attractive building block for pharmaceuticals where improved pharmacokinetic profiles are desired. In agrochemicals, these properties can translate to enhanced efficacy and persistence. The compound's reactivity at the amine group allows for a wide range of derivatizations, making it a versatile intermediate for complex organic transformations.

When considering the purchase of 4-(Trifluoromethoxy)aniline, understanding these properties is key. For instance, its flash point (around 177°F or 81°C) is important for handling and storage safety. Manufacturers also provide detailed Safety Data Sheets (SDS) that outline all necessary precautions. For businesses looking to source this compound, partnering with a reliable manufacturer in China ensures access to consistent quality, detailed technical documentation, and competitive pricing for both small and large quantities.

In essence, the synthesis and properties of 4-(Trifluoromethoxy)aniline underscore its importance as a high-value chemical intermediate. A thorough understanding of its characteristics empowers researchers and procurement specialists to effectively utilize this compound in their innovative projects.