For organic chemists and researchers pushing the boundaries of synthesis, understanding the properties and production of key reagents is fundamental. Ethyl Difluoroacetate (CAS 454-31-9) is one such compound, highly valued for its role as a versatile fluorinated building block. Its characteristic colorless to light brown transparent liquid appearance, coupled with specific physical properties, makes it a compound of interest for a wide range of applications, particularly in the pharmaceutical and agrochemical industries.

The synthesis of Ethyl Difluoroacetate typically involves careful control of reaction conditions and precise handling of fluorinating agents. One documented method, referenced in patent literature, involves the reaction of difluoroacetic acid fluoride with ethanol in the presence of N,N-dimethyl acetamide (DMAc). This process, when optimized with appropriate reaction times, temperatures, and purification techniques such as vacuum distillation, can yield Ethyl Difluoroacetate with high purity, often exceeding 98.8% area%. The ability of a manufacturer to consistently achieve such purity is a testament to their technical capabilities and quality control systems.

Key physical properties of Ethyl Difluoroacetate include a molecular weight of 124.09 g/mol, a density of approximately 1.242 g/cm³, and a boiling point around 97°C. Its flash point of 25°C indicates it is a flammable liquid, requiring appropriate handling and storage precautions. The refractive index, typically between 1.3465 and 1.3485, is another characteristic property used for quality assessment. These parameters are crucial for researchers when designing experiments and for procurement specialists when verifying product specifications from a potential supplier.

The utility of Ethyl Difluoroacetate extends beyond its intrinsic properties; it is its reactivity that makes it so valuable. As a difluoroacetate ester, it can readily participate in nucleophilic substitution reactions, ester hydrolysis, and other transformations. This reactivity allows for the introduction of the difluoroacetyl moiety into a variety of organic molecules. For those looking to purchase Ethyl Difluoroacetate for laboratory use, understanding these reaction pathways can help in designing efficient synthetic strategies.

The availability of this compound from reliable chemical suppliers is vital for academic institutions and industrial R&D departments. When evaluating potential vendors, it is important to inquire about their production capacity, quality assurance processes, and available packaging options. For those seeking to buy in bulk, discussing pricing and lead times with a dedicated manufacturer is a prudent approach. The consistent supply of high-quality Ethyl Difluoroacetate is essential for the seamless execution of complex synthetic projects, from early-stage research to pilot-scale production.

In summary, Ethyl Difluoroacetate's well-defined synthesis, characteristic physical properties, and versatile reactivity make it an indispensable reagent in modern organic chemistry. Researchers and procurement managers who understand these aspects are better equipped to source this critical compound effectively, driving innovation in the fields it serves.