For professionals in chemical procurement and research and development, understanding the properties and applications of key reagents is fundamental to successful operations. O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, widely known as TBTU and identified by its CAS number 125700-67-6, is a compound that warrants significant attention within the scientific community, particularly in the field of peptide synthesis.

TBTU is a highly effective uronium-based coupling reagent. Its primary function is to activate carboxyl groups, forming an active ester intermediate that readily reacts with amines to create amide bonds. This process is fundamental to building peptide chains, where amino acids are sequentially linked. The efficiency and mild reaction conditions offered by TBTU contribute to higher yields and reduced racemization, a critical concern when synthesizing biologically active peptides. For scientists looking to buy TBTU, recognizing its role in facilitating these precise chemical transformations is key.

When engaging with TBTU manufacturers, particularly those in China, buyers should focus on product specifications such as purity, molecular weight (321.08 g/mol), and chemical formula (C11H16BF4N5O). High purity, typically 98% or 99%, is essential for preventing unwanted side reactions and ensuring the integrity of the synthesized peptides. Procurement managers often compare TBTU reagent prices from different suppliers to secure the best value without compromising on quality. Phrases like “TBTU tetrafluoroborate price” or “buy TBTU for custom synthesis” are common search terms for those sourcing this compound.

The applications of TBTU extend beyond basic peptide synthesis. It is also utilized as an intermediate in the production of various fine chemicals and pharmaceuticals. Its reliable performance makes it a go-to reagent for many organic chemists involved in complex molecular synthesis. For researchers needing to purchase TBTU, working with established chemical suppliers that provide documentation such as Certificates of Analysis (CoA) is advisable. This ensures traceability and confirms that the product meets stringent quality standards.

In summary, TBTU (CAS 125700-67-6) is a vital reagent for advanced chemical synthesis. Whether you are a researcher performing intricate peptide syntheses or a procurement specialist sourcing critical intermediates, understanding its capabilities and reliable sourcing channels, especially from China-based manufacturers, will greatly contribute to your project's success. Effective sourcing of TBTU can lead to more efficient, cost-effective, and high-quality outcomes.