Navigating the complex world of chemical reagents can be challenging, especially when seeking efficient and reliable compounds for synthesis. TBTU, scientifically known as O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate (CAS 125700-67-6), is a cornerstone coupling reagent widely utilized in various chemical transformations. This guide provides R&D scientists, procurement managers, and chemists with a clear understanding of TBTU's properties, applications, and how to effectively purchase it.

TBTU is characterized as a white powder, offering excellent stability under recommended storage conditions. Its chemical structure provides robust activation of carboxylic acids, enabling the formation of amide and ester bonds with high efficiency. The key advantage of TBTU is its role in facilitating these reactions rapidly, often in situ, while significantly minimizing racemization – a critical factor in chiral synthesis and peptide chemistry. For anyone looking to buy TBTU, these properties underscore its value.

The primary applications for TBTU include its indispensable role in solid-phase peptide synthesis (SPPS) and solution-phase peptide synthesis. It is also a highly effective reagent for general amide and ester formation, making it a versatile tool for organic chemists. Furthermore, TBTU has proven utility in the synthesis of more complex structures like aza-peptides. Understanding these diverse applications helps purchasers identify the most suitable reagent for their specific synthetic goals.

When considering TBTU as a purchasing option, several factors come into play. Firstly, the purity of the TBTU is paramount; higher purity ensures more predictable and reproducible results, which is essential for both R&D and manufacturing. Secondly, the reliability of the supplier is crucial. Sourcing from established manufacturers, such as those in China who offer competitive TBTU prices, ensures a consistent supply chain and dependable product quality. Always request a Certificate of Analysis (CoA) to verify purity and specifications.

The ease of handling and broad solvent compatibility of TBTU further enhance its appeal. Its ability to dissolve in common organic solvents and even water simplifies reaction setup and workup, contributing to process efficiency. This makes it a practical choice for laboratories and production facilities with varying equipment and protocols.

As a leading TBTU manufacturer, we are committed to providing high-quality, high-purity TBTU to meet the diverse needs of the chemical industry. We invite you to explore our product offerings and discover the benefits of partnering with a reliable supplier. Contact us today for TBTU pricing, availability, and to discuss how our reagents can support your synthesis projects, from laboratory research to industrial-scale production.