Tert-Butyl bromoacetate, bearing the CAS number 5292-43-3, is a chemical compound whose significance spans across various industrial applications, most notably in pharmaceuticals and organic synthesis. Scientifically known as tert-butyl 2-bromoacetate, this substance presents as a colorless to slightly yellow clear liquid. Its molecular formula is C6H11BrO2, and it possesses a molecular weight of approximately 195.06 g/mol. These fundamental characteristics provide a baseline for understanding its chemical behavior and utility.

The synthesis of Tert-Butyl bromoacetate is typically achieved through a reaction involving tert-butanol and bromoacetyl bromide. This esterification process is carried out under controlled conditions to ensure a high yield and purity of the final product. Modern manufacturing processes, often found with suppliers in China, focus on optimizing these synthetic routes to achieve greater efficiency and reduce environmental impact. The ability to produce this compound reliably and cost-effectively is crucial for its widespread adoption in industries that rely on it as a key ingredient.

One of the primary applications of Tert-Butyl bromoacetate is its role as a pharmaceutical intermediate. It is extensively used in the synthesis of amino acids and peptide compounds, which are the fundamental building blocks for many complex pharmaceuticals and biotechnological products. Its function as an alkylating agent further amplifies its importance in organic chemistry. This property allows for the introduction of specific alkyl groups into molecules, a process vital for creating novel compounds with desired functionalities or for modifying existing ones to enhance their therapeutic efficacy. For example, it serves as a reagent in the synthesis of inhibitors for enzymes like collagenase, which are targets in various disease treatments.

The physical and chemical properties of Tert-Butyl bromoacetate, such as its density of around 1.33 g/cm³ and a flash point typically around 49-50°C, dictate its handling and storage requirements. Being a flammable liquid, it must be stored in cool, well-ventilated areas, away from ignition sources. Its solubility in organic solvents like ethanol and ethyl acetate, and insolubility in water, also influences its application in different reaction mediums. Companies like NINGBO INNO PHARMCHEM CO.,LTD. ensure that their Tert-Butyl bromoacetate products meet high standards of purity and are packaged appropriately for safe transport and storage.

In conclusion, Tert-Butyl bromoacetate (CAS 5292-43-3) is a versatile and indispensable chemical. Its critical role in synthesizing pharmaceutical intermediates and its effectiveness as an alkylating agent make it a highly sought-after compound. Understanding its properties, synthesis, and applications is key for researchers and manufacturers in the chemical and pharmaceutical sectors looking to source this essential material from reliable global suppliers.