Tert-Butyl Carbamate (CAS 4248-19-5) is a versatile organic compound widely employed across several scientific disciplines, most notably in organic synthesis and pharmaceutical development. Understanding its chemical properties, synthesis routes, and applications is crucial for chemists and researchers aiming to leverage its capabilities.

Chemically, Tert-Butyl Carbamate is a carbamate derivative with a tert-butyl group attached to the nitrogen. It typically appears as white to slightly yellowish needle-like crystals with a purity of ≥ 99%. Its solubility profile is noteworthy; it readily dissolves in ethanol and ether, exhibits slight solubility in chloroform and methanol, is sparingly soluble in petroleum ether, and is almost insoluble in water. These properties facilitate its use in a variety of reaction media.

The synthesis of Tert-Butyl Carbamate can be achieved through several methods. One common approach involves the reaction of amines with tert-butyl chloroformate or di-tert-butyl dicarbonate. Another significant pathway utilizes the Curtius rearrangement of tert-butyl azidoformate. As a supplier, we ensure that our Tert-Butyl Carbamate is produced through efficient and controlled processes to maintain high purity and consistency.

In organic synthesis, Tert-Butyl Carbamate is highly valued as a protecting group for amines, particularly in peptide synthesis. Its ability to be installed and removed under mild conditions makes it an efficient tool for selective functionalization. Beyond this, it serves as a crucial intermediate in the synthesis of various organic compounds and plays a role in the agricultural sector as a precursor for insecticides and fungicides. For those looking to buy Tert-Butyl Carbamate, partnering with a reliable manufacturer in China ensures access to a quality product essential for R&D and production.