In the realm of advanced chemical synthesis, understanding the fundamental properties of a compound is crucial for its effective application. Methyl 2-Oxoindoline-6-carboxylate (CAS 14192-26-8) is a prime example of a fine chemical intermediate whose specific characteristics make it invaluable in pharmaceutical research and manufacturing. This article delves into its key chemical and physical attributes, alongside its significant applications, providing insights for scientists and procurement professionals.

Methyl 2-Oxoindoline-6-carboxylate presents itself as an off-white powder, a physical form that aids in its handling and incorporation into various reaction systems. Its molecular formula, C10H9NO3, and molecular weight of 191.18300, define its chemical identity. The compound exhibits a melting point typically between 184-190ºC, indicating reasonable thermal stability. Its boiling point is recorded at 388.1ºC, and it has a flash point of 107ºC, parameters that are essential for safe storage and processing. The density is approximately 1.283 g/cm³ and its refractive index is 1.572, offering further insights for laboratory use.

The primary industrial application for Methyl 2-Oxoindoline-6-carboxylate is its role as a key intermediate in the synthesis of Nintedanib. Nintedanib is a vital drug utilized in the treatment of severe medical conditions like idiopathic pulmonary fibrosis and certain types of cancer. The high purity of Methyl 2-Oxoindoline-6-carboxylate, often specified as ≥98.0%, is critical to ensure the successful synthesis of Nintedanib and to maintain the efficacy and safety of the final pharmaceutical product. This stringent purity requirement means that when you seek to purchase this intermediate, you must partner with reliable manufacturers who adhere to rigorous quality control standards.

Beyond its principal use, Methyl 2-Oxoindoline-6-carboxylate also serves as a valuable building block in broader organic synthesis and medicinal chemistry research. Its indole core structure is a common motif in many biologically active molecules, making it an attractive starting material for developing new therapeutic agents. Researchers can leverage its reactivity to create novel compounds for drug discovery programs. For those looking to buy this versatile chemical, exploring options from established suppliers, especially those specializing in pharmaceutical intermediates, is recommended. The availability of this compound from manufacturers in China, often with competitive pricing and reliable supply chains, further supports its widespread use in scientific and industrial endeavors.