The utility of a chemical compound in industrial applications is intrinsically linked to its molecular structure and the resulting chemical properties. For 1-(2-Hydroxyethyl)piperazine (CAS 103-76-4), its bifunctional nature—possessing both a hydroxyl group (-OH) and a secondary amine within a piperazine ring—dictates its reactivity and broad applicability in diverse synthesis pathways. Understanding these properties is essential for R&D scientists and chemists seeking to leverage this compound for novel material development or pharmaceutical production.

The molecular formula of 1-(2-Hydroxyethyl)piperazine is C6H14N2O, with a molecular weight of approximately 130.19 g/mol. Its structure features a six-membered piperazine ring, a heterocyclic diamine, with one nitrogen atom substituted by a 2-hydroxyethyl group. This hydroxyethyl moiety imparts polarity and hydrogen bonding capabilities, enhancing its solubility in water and other polar solvents, a characteristic often observed in its clear, colorless to pale yellow oily liquid appearance. This solubility is a significant advantage in many synthesis processes that are conducted in aqueous or polar organic media.

The piperazine ring itself contains two nitrogen atoms, both of which are nucleophilic. The secondary amine nitrogen atom, being less sterically hindered than if it were tertiary, readily participates in a variety of reactions. It can undergo alkylation, acylation, and condensation reactions, serving as a key point for building larger molecular structures. The presence of the hydroxyl group on the ethyl side chain adds another dimension of reactivity. This primary alcohol can be esterified, etherified, oxidized, or undergo nucleophilic substitution reactions, further expanding the synthetic possibilities. This dual functionality makes 1-(2-Hydroxyethyl)piperazine a versatile building block for creating complex organic molecules.

In the realm of pharmaceutical synthesis, these properties allow chemists to readily attach desired pharmacophores to the piperazine core or modify the hydroxyethyl group to fine-tune the pharmacokinetic or pharmacodynamic profiles of potential drug candidates. For example, its use as an intermediate in the synthesis of antipsychotic drugs leverages the ability to further functionalize both the amine and alcohol groups to achieve specific therapeutic effects. Similarly, in the development of specialized surfactants or polymers, the amphiphilic nature that can be imparted by modifying these functional groups is highly valuable.

For companies looking to buy 1-(2-Hydroxyethyl)piperazine for their synthesis needs, partnering with manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. ensures access to material with well-defined properties and high purity. A reliable supplier provides not only the chemical but also the assurance that its reactivity will be consistent, leading to predictable outcomes in your synthesis endeavors. Understanding these chemical properties empowers chemists to design more efficient and effective synthesis routes, ultimately accelerating innovation in drug discovery, material science, and beyond. Inquire about this essential chemical today to unlock new possibilities in your research and manufacturing.