2,2,2-Trichloroethanol, identified by its CAS number 115-20-8, is a fascinating chemical intermediate whose properties dictate its diverse applications. NINGBO INNO PHARMCHEM CO.,LTD. provides this compound, ensuring it meets the necessary specifications for its intended uses in synthesis and industry. Understanding its chemical properties is key to its effective utilization.

Physically, 2,2,2-Trichloroethanol is typically described as a clear, colorless to light yellow liquid. Its melting point is around 17.8 °C, and it has a boiling point of approximately 152-154 °C. The density is about 1.56 g/mL at 20 °C. These physical characteristics are important considerations for handling, storage, and processing. The solubility of 2,2,2-Trichloroethanol is notable; it is soluble in water to some extent (83 g/L) and also in common organic solvents like alcohol and ether, which enhances its versatility in various reaction media.


Chemically, the presence of three chlorine atoms on the ethyl group significantly influences the reactivity of 2,2,2-Trichloroethanol. The hydroxyl group allows it to participate in esterification and etherification reactions. As mentioned in guides on the uses of 2,2,2-Trichloroethanol in synthesis, it is particularly valued for its ability to act as a precursor to the 2,2,2-trichloroethyl (TCE) protecting group. This group is favored for its stability under a range of conditions and its facile removal via reductive cleavage, typically with zinc. This chemical behavior makes it a reliable component in complex synthetic pathways.


The pKa of 2,2,2-Trichloroethanol is approximately 12.24 at 25 °C, indicating it is a weak acid. Safety data also highlights potential hazards, such as moderate toxicity and the need for careful handling. NINGBO INNO PHARMCHEM CO.,LTD. provides comprehensive information to ensure that users are aware of these properties and can handle the compound safely. By understanding these chemical and physical properties, researchers and industrial users can better leverage 2,2,2-Trichloroethanol for their specific chemical synthesis needs.