NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing chemists with detailed information about the compounds we supply, enabling more effective and informed research. Today, we focus on 3-Bromo-2,4-difluoroaniline (CAS: 103977-79-3), delving into its chemical properties and structural significance in the context of advanced synthesis.

3-Bromo-2,4-difluoroaniline is characterized by its molecular formula C6H4BrF2N and a molecular weight of approximately 208.01 g/mol. It features an aniline core substituted with a bromine atom at the 3-position and fluorine atoms at the 2 and 4 positions. This specific arrangement of halogens on the aromatic ring imparts unique electronic and steric characteristics that are highly valued in organic synthesis. The precise control over 3-bromo-2,4-difluoroaniline synthesis ensures the correct positioning of these influential functional groups.

Key physical properties include a predicted boiling point of 224.8±35.0 °C and a density of 1.788±0.06 g/cm3. It is typically stored under an inert atmosphere, such as nitrogen or argon, at refrigerated temperatures (2–8 °C) to maintain its stability and purity. These conditions are crucial for preserving its reactivity and ensuring its suitability as one of the vital organic synthesis building blocks.

The chemical reactivity of 3-Bromo-2,4-difluoroaniline stems from its amine group and the activated aromatic ring. The amine group can undergo acylation, alkylation, and diazotization reactions, while the bromine atom is highly amenable to palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura, Sonogashira, and Buchwald-Hartwig couplings. These reactions are fundamental in constructing complex carbon frameworks and are extensively used in chemical intermediates for drug discovery.

The influence of the fluorine atoms on the molecule's properties is noteworthy. They can increase the compound's lipophilicity, enhance metabolic stability in biological systems, and modify its electronic distribution, thereby influencing its reactivity in subsequent synthetic steps. Understanding these nuances is key to effectively utilizing the diverse fluoroaniline derivatives applications. For researchers looking to buy 3-bromo-2,4-difluoroaniline CAS 103977-79-3, knowledge of these properties is essential for planning successful syntheses.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality chemical products. Our 3-Bromo-2,4-difluoroaniline is produced under strict quality control measures to ensure it meets the demanding requirements of modern chemical research and development. We aim to facilitate your work by providing reliable and well-characterized chemical intermediates.

In conclusion, a thorough understanding of the chemical properties of 3-Bromo-2,4-difluoroaniline is fundamental for its effective application in advanced synthetic chemistry. NINGBO INNO PHARMCHEM CO.,LTD. is proud to supply this important intermediate, supporting the ongoing innovations in the field.