Understanding the Chemical Properties of 3-Fluoro-5-methoxyaniline (CAS: 2339-58-4)
When embarking on complex chemical synthesis projects, a thorough understanding of the properties of the starting materials is essential for success. 3-Fluoro-5-methoxyaniline, bearing the CAS registry number 2339-58-4, is a compound of significant interest within the realm of organic intermediates. Its specific molecular structure, C7H8FNO, and associated physicochemical data provide crucial insights into its behavior and potential applications.
Key to its utility is its molecular weight of 141.14, a factor that influences stoichiometry in reactions. The compound's boiling point, approximately 226.2°C at standard atmospheric pressure, indicates its thermal stability and volatility. Its flash point, recorded at 90.6°C, is a critical safety parameter, defining its flammability characteristics. Furthermore, its density of 1.176 g/cm³ and a refractive index of 1.531 contribute to its physical identification and handling procedures. These figures are not merely academic; they directly inform how the material should be stored, transported, and utilized in laboratory or industrial settings.
The chemical composition of 3-Fluoro-5-methoxyaniline, featuring a fluorine atom and a methoxy group attached to an aniline core, grants it a unique reactivity profile. The fluorine substituent can significantly alter electron distribution within the aromatic ring, influencing reaction rates and regioselectivity in electrophilic aromatic substitution and other common organic transformations. The methoxy group provides further electronic modulation and can participate in various reactions as well. This dual functionality makes it a versatile intermediate for chemists aiming to construct more complex molecules, particularly in fields like medicinal chemistry and material science.
For professionals seeking reliable synthesis materials, information regarding availability, packaging options, and appropriate storage conditions is equally important. Typically, compounds like 3-Fluoro-5-methoxyaniline are supplied in various quantities, ranging from grams for laboratory research to kilograms for pilot-scale or industrial production. Proper storage, usually in tightly closed containers in cool, dry, and well-ventilated areas away from incompatible substances, is crucial to maintain its quality and purity over time. The pursuit of high-quality intermediates like 3-Amino-5-fluoroanisole is a cornerstone for advancing chemical innovation, ensuring predictable outcomes in research and manufacturing.
Perspectives & Insights
Chem Catalyst Pro
“The fluorine substituent can significantly alter electron distribution within the aromatic ring, influencing reaction rates and regioselectivity in electrophilic aromatic substitution and other common organic transformations.”
Agile Thinker 7
“The methoxy group provides further electronic modulation and can participate in various reactions as well.”
Logic Spark 24
“This dual functionality makes it a versatile intermediate for chemists aiming to construct more complex molecules, particularly in fields like medicinal chemistry and material science.”