The efficacy of modern pharmaceuticals is built upon a foundation of sophisticated chemical synthesis. For drugs like Febuxostat, which target conditions such as hyperuricemia, the intermediate compounds used are as important as the final API. Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate (CAS: 161798-01-2) is a prime example of such a crucial intermediate. Understanding its chemical structure and how it is synthesized provides valuable insight into the precision required in pharmaceutical manufacturing.

Chemically, Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate is a complex organic molecule. Its structure includes a thiazole ring, which is a five-membered heterocyclic ring containing both sulfur and nitrogen atoms. Attached to this core are several functional groups: an ethyl ester group (-COOCH2CH3), a methyl group (-CH3), a hydroxyphenyl group (-C6H4OH), and importantly, a formyl group (-CHO). The presence and precise positioning of these groups, particularly the formyl and hydroxyl groups on the phenyl ring, are critical for its role in the subsequent synthesis of Febuxostat. The molecular formula C14H13NO4S and a molecular weight of 291.32 further define its chemical identity.

The synthesis of this intermediate typically involves multi-step organic reactions. While specific proprietary methods may vary, a common approach found in literature and patents involves the formylation of a precursor. For instance, a method might start with ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate and introduce the formyl group using reagents like hexamethylenetetramine (HMTA) in the presence of polyphosphoric acid. This process requires careful control of reaction temperatures, times, and reagent concentrations to ensure high yield and purity. The resulting compound is usually isolated as a yellow powder, as detailed in specifications.

For manufacturers, sourcing this intermediate reliably is key to consistent Febuxostat production. NINGBO INNO PHARMCHEM CO.,LTD. focuses on providing this compound with high purity (u226599.0%), ensuring it meets the demanding requirements for pharmaceutical applications. The ability to 'purchase' this intermediate with confidence allows drug developers to focus on formulation and clinical trials, knowing their supply chain is secure. The 'price' is a factor, but the chemical integrity and consistent 'buy' experience are paramount for successful drug development.

In summary, the detailed understanding of the chemical structure and synthesis of Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate underscores its significance. It is not merely a chemical but a precisely engineered component essential for creating medications that improve patient quality of life. Companies like NINGBO INNO PHARMCHEM CO.,LTD. are dedicated to supplying this vital building block, supporting the broader goals of healthcare innovation.