For chemists and R&D professionals, a deep understanding of a chemical's properties is fundamental to its successful application. 4-(Methylsulfonyl)phenylacetic Acid, a key intermediate in organic synthesis, offers a unique set of characteristics that make it valuable in various industrial processes. Examining its physical and chemical properties provides critical insights for formulators and researchers aiming to optimize their synthesis routes.

One of the most immediately discernible properties of 4-(Methylsulfonyl)phenylacetic Acid (CAS No.: 90536-66-6) is its appearance. It is typically described as a white to light yellow crystalline powder. This physical state is indicative of its solid nature at room temperature, which simplifies handling and storage compared to liquids or gases. The crystalline structure also suggests a degree of purity, although specific assay values are essential for confirmation.

Regarding its thermal properties, the melting point of 4-(Methylsulfonyl)phenylacetic Acid is reported in literature to be around 136-140 °C. This relatively sharp melting range indicates a well-defined compound. Its boiling point, estimated to be significantly higher, suggests thermal stability under typical processing conditions, though decomposition points should always be considered in high-temperature reactions. Solubility is another crucial factor; this compound exhibits slight solubility in DMSO and methanol, suggesting it can be incorporated into specific solvent systems for reactions.

Chemically, 4-(Methylsulfonyl)phenylacetic Acid possesses a phenylacetic acid core functionalized with a methylsulfonyl group. The presence of the carboxylic acid group (-COOH) allows it to participate in esterification, amidation, and salt formation reactions. The sulfonyl group (-SO2CH3) is electron-withdrawing, influencing the reactivity of the aromatic ring and the acidity of the carboxylic proton. These structural features are precisely why it serves as an effective intermediate in the synthesis of more complex molecules, particularly pharmaceuticals like Etoricoxib and various agrochemicals.

For professionals looking to purchase 4-(Methylsulfonyl)phenylacetic Acid, understanding these properties is key to selecting the right manufacturer and ensuring product suitability. A reliable supplier will provide detailed specifications that confirm these properties, such as exact melting point ranges, purity assays (e.g., ≥96.0%), and solubility data. When sourcing from China, it's always advisable to verify that the supplier’s product meets the required quality standards for your specific application.

In summary, the crystalline nature, defined melting point, and specific solubility profile of 4-(Methylsulfonyl)phenylacetic Acid, coupled with its reactive functional groups, make it a highly valuable intermediate. Thorough consideration of these chemical and physical attributes empowers researchers and procurement specialists to make informed decisions and achieve successful synthesis outcomes.