Understanding the Properties and Handling of 2-Chloroethyl Isocyanate
The safe and effective use of any chemical compound begins with a thorough understanding of its properties. 2-Chloroethyl isocyanate, with the CAS number 1943-83-5, is a reactive chemical intermediate that demands careful attention to its characteristics and handling requirements.
Physically, 2-Chloroethyl isocyanate is typically described as a clear, colorless to slightly yellow liquid. It possesses a pungent odor, indicative of its reactive nature. Key physical parameters include a boiling point generally reported around 141-142 °C, a density of approximately 1.237 g/mL at 25 °C, and a refractive index of around 1.447. Its flash point is around 56 °C (135 °F), classifying it as a flammable liquid.
Chemically, the isocyanate group (-NCO) is highly reactive, particularly towards nucleophiles such as water, alcohols, and amines. Its reaction with water (hydrolysis) leads to the formation of corresponding amines and carbon dioxide, which can build up pressure in a sealed container. This sensitivity to moisture means that 2-Chloroethyl isocyanate must be stored under dry conditions, preferably under an inert atmosphere like nitrogen, to maintain its integrity and prevent degradation.
Safety is a paramount concern when working with 2-Chloroethyl isocyanate. It is known to be a lachrymator, meaning it can cause irritation and tearing of the eyes. Furthermore, due to its reactive and potentially toxic nature, it is classified with hazard statements such as 'Fatal if swallowed' and 'Fatal if inhaled.' Appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles, a face shield, and respiratory protection, is essential when handling this compound. All operations should be conducted in a well-ventilated area or a fume hood.
NINGBO INNO PHARMCHEM CO.,LTD., as a responsible manufacturer and supplier, provides comprehensive safety data sheets (SDS) for 2-Chloroethyl isocyanate. These documents detail the hazards, safe handling procedures, first-aid measures, and emergency response protocols. Proper storage is also critical; it is typically recommended to store the compound at low temperatures, around 2-8 °C, in tightly sealed containers to prevent moisture ingress and degradation.
For researchers and industrial chemists looking to buy 2-Chloroethyl isocyanate, understanding these properties and handling guidelines is non-negotiable. Adhering to these recommendations ensures both personal safety and the successful application of this versatile chemical intermediate in various synthesis processes, whether in pharmaceutical development or agrochemical production.
Physically, 2-Chloroethyl isocyanate is typically described as a clear, colorless to slightly yellow liquid. It possesses a pungent odor, indicative of its reactive nature. Key physical parameters include a boiling point generally reported around 141-142 °C, a density of approximately 1.237 g/mL at 25 °C, and a refractive index of around 1.447. Its flash point is around 56 °C (135 °F), classifying it as a flammable liquid.
Chemically, the isocyanate group (-NCO) is highly reactive, particularly towards nucleophiles such as water, alcohols, and amines. Its reaction with water (hydrolysis) leads to the formation of corresponding amines and carbon dioxide, which can build up pressure in a sealed container. This sensitivity to moisture means that 2-Chloroethyl isocyanate must be stored under dry conditions, preferably under an inert atmosphere like nitrogen, to maintain its integrity and prevent degradation.
Safety is a paramount concern when working with 2-Chloroethyl isocyanate. It is known to be a lachrymator, meaning it can cause irritation and tearing of the eyes. Furthermore, due to its reactive and potentially toxic nature, it is classified with hazard statements such as 'Fatal if swallowed' and 'Fatal if inhaled.' Appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles, a face shield, and respiratory protection, is essential when handling this compound. All operations should be conducted in a well-ventilated area or a fume hood.
NINGBO INNO PHARMCHEM CO.,LTD., as a responsible manufacturer and supplier, provides comprehensive safety data sheets (SDS) for 2-Chloroethyl isocyanate. These documents detail the hazards, safe handling procedures, first-aid measures, and emergency response protocols. Proper storage is also critical; it is typically recommended to store the compound at low temperatures, around 2-8 °C, in tightly sealed containers to prevent moisture ingress and degradation.
For researchers and industrial chemists looking to buy 2-Chloroethyl isocyanate, understanding these properties and handling guidelines is non-negotiable. Adhering to these recommendations ensures both personal safety and the successful application of this versatile chemical intermediate in various synthesis processes, whether in pharmaceutical development or agrochemical production.
Perspectives & Insights
Molecule Vision 7
“Chemically, the isocyanate group (-NCO) is highly reactive, particularly towards nucleophiles such as water, alcohols, and amines.”
Alpha Origin 24
“Its reaction with water (hydrolysis) leads to the formation of corresponding amines and carbon dioxide, which can build up pressure in a sealed container.”
Future Analyst X
“This sensitivity to moisture means that 2-Chloroethyl isocyanate must be stored under dry conditions, preferably under an inert atmosphere like nitrogen, to maintain its integrity and prevent degradation.”