For professionals in the B2B chemical and pharmaceutical sectors, detailed knowledge of key intermediates is essential for effective product development and supply chain management. 4-(Bromomethyl)-3-fluorobenzonitrile, identified by CAS number 105942-09-4, is a compound of significant interest due to its versatile chemical nature and application in critical industries. This article aims to provide a comprehensive understanding of its properties and how to approach its procurement.

Physical and Chemical Characteristics:

4-(Bromomethyl)-3-fluorobenzonitrile is typically supplied as a white powder, indicating its solid state at room temperature. Its molecular formula is C8H5BrFN, with a molecular weight of 214.03 g/mol. The density is recorded as 1.59 g/cm³, and it possesses a boiling point of 276.4 °C at standard atmospheric pressure (760 mmHg). A flash point of 121 °C is also noted, which is relevant for safety considerations during handling and storage. The purity of this compound is often specified at 98%, a critical factor for its use in high-specification applications such as pharmaceutical intermediates and advanced materials.

The reactivity of 4-(Bromomethyl)-3-fluorobenzonitrile stems from its functional groups. The bromomethyl moiety (-CH2Br) is an excellent leaving group, making the molecule susceptible to nucleophilic substitution reactions. This allows for the introduction of various functional groups, leading to the synthesis of more complex molecules. The nitrile group (-CN) and the fluorine atom (-F) on the aromatic ring also influence the compound's electronic properties and can participate in or direct further reactions, making it a highly adaptable building block for organic synthesis.

Key Applications:

The utility of 4-(Bromomethyl)-3-fluorobenzonitrile spans several high-value industries:

  • Pharmaceutical Intermediates: It serves as a crucial starting material or intermediate in the synthesis of Active Pharmaceutical Ingredients (APIs). Its fluorinated structure can impart desirable properties to the final drug product. For companies looking to buy these intermediates, ensuring high purity is vital for drug efficacy and safety.
  • UV-Curing Materials: This compound plays a role in the development of photoinitiators used in UV-curable inks, coatings, and adhesives. These materials are essential for fast-drying, durable finishes in various manufacturing processes.
  • Cosmetics and Specialty Chemicals: Its unique properties can also be leveraged in the formulation of certain cosmetic products and in other niche areas of fine chemical synthesis.

Procurement Strategies from China:

Given its importance, securing a reliable supply of 4-(Bromomethyl)-3-fluorobenzonitrile is a priority for many businesses. China has become a prominent source for such chemical intermediates, offering both competitive pricing and significant production capacity. When seeking to purchase this compound, prospective buyers should:

  1. Identify Reputable Manufacturers/Suppliers: Look for companies with established track records, ISO certifications, and transparent communication channels.
  2. Request Detailed Specifications and CoAs: Always verify the purity (98%) and other technical data against your requirements.
  3. Compare Pricing and Minimum Order Quantities (MOQs): Obtain quotes for your desired quantities, considering both spot purchases and long-term supply agreements.
  4. Assess Lead Times and Logistics: Understand the production and shipping timelines to ensure they align with your project schedules.

Working with experienced manufacturers and suppliers in China allows for access to cost-effective solutions without compromising on quality, provided due diligence is performed. For any inquiry regarding price or availability, engaging directly with these suppliers is the most efficient approach.

In conclusion, 4-(Bromomethyl)-3-fluorobenzonitrile is a chemically significant intermediate with diverse applications. Understanding its properties and adopting a strategic approach to sourcing from reliable manufacturers and suppliers, particularly in China, is key to maintaining a competitive edge in today's demanding industrial landscape.