For chemists and procurement specialists in the B2B chemical industry, a deep understanding of a compound's properties and synthesis is crucial for successful application and sourcing. Methyl 5-bromo-2-chloroisonicotinate, bearing the CAS number 886365-28-2, is a prime example of a chemical intermediate whose characteristics make it highly sought after in various advanced manufacturing sectors, particularly pharmaceuticals and agrochemicals.

This compound, known chemically as Methyl 5-bromo-2-chloropyridine-4-carboxylate, possesses a molecular formula of C7H5BrClNO2 and a molecular weight of approximately 250.48 g/mol. Its physical form is typically described as an off-white crystalline powder, indicating a solid state at room temperature. Key physical and chemical properties reported include a density around 1.7 g/cm³, a boiling point of approximately 286.5 °C at 760 mmHg, and a flash point of around 127.1 °C. These specifications are vital for chemists when designing reaction conditions and handling the material safely.

The synthesis of Methyl 5-bromo-2-chloroisonicotinate likely involves multi-step organic reactions, starting from more basic pyridine derivatives. While specific proprietary synthesis routes may vary among manufacturers, typical methods would involve halogenation (bromination and chlorination) and esterification steps. For instance, a common precursor might be 2-chloroisonicotinic acid or its derivatives, which then undergo bromination and subsequent esterification with methanol. The precise sequence and conditions are optimized by manufacturers to achieve high yields and the required purity levels, often 98.0% or greater, as specified by buyers.

The significance of Methyl 5-bromo-2-chloroisonicotinate lies in its utility as a versatile building block. The strategically positioned halogen atoms (bromine and chlorine) offer distinct reactivity profiles, enabling diverse synthetic transformations such as cross-coupling reactions (e.g., Suzuki, Stille, Buchwald-Hartwig), nucleophilic aromatic substitutions, and metallation reactions. These reactions are fundamental for constructing complex molecular architectures used in pharmaceuticals, agrochemicals, and materials science.

For businesses seeking to purchase this compound, understanding these properties is paramount. When you buy Methyl 5-bromo-2-chloroisonicotinate, it's essential to partner with a manufacturer or supplier that can provide detailed technical documentation, including a Certificate of Analysis (COA) confirming purity and specifications, and a Safety Data Sheet (SDS) for safe handling. Reliable suppliers, especially those operating in China, are equipped to meet these demands and can offer competitive pricing for bulk quantities.

In conclusion, Methyl 5-bromo-2-chloroisonicotinate is a critical intermediate whose chemical properties and accessible synthesis pathways underpin its importance. By understanding its characteristics, researchers and procurement managers can effectively source this compound to drive innovation in their respective fields.