For chemists and material scientists, a thorough understanding of a compound's properties is the bedrock of successful synthesis and application. 2-Bromo-5-chlorothiophene (CAS 2873-18-9) is a prime example of an intermediate whose utility is directly tied to its distinct physical and chemical characteristics. As a widely used building block, appreciating these properties is crucial for anyone looking to buy or utilize this valuable chemical.

Physically, 2-bromo-5-chlorothiophene is classified as a liquid at room temperature. This is partly indicated by its relatively low melting point and its boiling point, which is typically around 69-70 °C at 18 mmHg. Its density, measured at approximately 1.803 g/mL at 25 °C, suggests it is a relatively heavy liquid compared to water. The refractive index, n20/D of 1.596, is another key physical parameter, often used for purity assessment and identification. These liquid properties facilitate ease of handling, measurement, and introduction into various reaction systems, making it convenient for both laboratory and industrial-scale operations. When you seek to purchase this compound, these physical attributes inform how it will be stored, transported, and used in your processes.

Chemically, the thiophene ring itself is an electron-rich aromatic heterocycle. The presence of the bromine and chlorine substituents significantly influences its reactivity. As mentioned previously, the halogens can be selectively manipulated. The C-Br bond is generally more susceptible to oxidative addition in palladium-catalyzed cross-coupling reactions than the C-Cl bond. This difference in reactivity is a cornerstone of its versatility, allowing for sequential functionalization. Furthermore, the electron-withdrawing nature of the halogens can also influence the reactivity of the thiophene ring itself, potentially making it more amenable to certain nucleophilic attack or electrophilic substitution under specific conditions.

These chemical properties are precisely why 2-bromo-5-chlorothiophene is such a sought-after intermediate in the synthesis of pharmaceuticals, agrochemicals, and electronic materials. For instance, in pharmaceutical research, it can be a key component in constructing complex molecular architectures that form the basis of new drug candidates. In the field of materials science, its thiophene backbone can be incorporated into conjugated systems for organic electronics.

When considering the purchase of 2-bromo-5-chlorothiophene, understanding these properties empowers you to make informed decisions. Knowing its physical state and reactivity allows for better planning of synthetic routes and ensures that the material is suitable for your specific application. As a dedicated supplier, we emphasize the quality and consistency of our 2-bromo-5-chlorothiophene, ensuring that its well-defined properties meet the demands of your advanced chemical synthesis needs. Contact us to buy high-purity material for your next project.