For chemists, formulators, and procurement specialists in the pharmaceutical and fine chemical industries, a thorough understanding of raw material properties is essential for successful product development and manufacturing. 3-Ethoxy-4-methoxybenzonitrile (CAS 60758-86-3) is one such compound, critical for various synthesis pathways, most notably in the production of Apremilast.

Key Chemical and Physical Attributes

3-Ethoxy-4-methoxybenzonitrile is characterized by its molecular formula C10H11NO2 and a molecular weight of 177.200. As a white powder, its handling and integration into synthesis processes are generally straightforward. Critical specifications and properties that R&D scientists and purchasing managers need to consider include:

  • Appearance: White Powder
  • Assay: ≥99.0% (ensuring high purity for critical applications)
  • Loss on Drying: ≤0.5% (indicating low moisture content)
  • Sulphate Ash: ≤0.1% (reflecting minimal inorganic impurities)
  • Density: Approximately 1.1±0.1 g/cm3 (relevant for bulk handling and formulation)
  • Boiling Point: 281.9±25.0 °C at 760 mmHg (important for process design)
  • Flash Point: 109.2±16.4 °C (a safety consideration for storage and handling)
  • PSA: 42.25000 (indicates polarity, relevant for solubility and reactivity)
  • LogP: 2.10 (suggests moderate lipophilicity)

These detailed specifications are vital for anyone looking to buy 3-ethoxy-4-methoxybenzonitrile, particularly when planning chemical reactions or formulating products where precise control over physical and chemical behavior is necessary. Understanding these properties allows for better process optimization and troubleshooting.

Applications and Sourcing Considerations

Primarily, 3-ethoxy-4-methoxybenzonitrile serves as a crucial pharmaceutical intermediate for the synthesis of Apremilast. Its unique chemical structure makes it an indispensable building block. When sourcing this material, particularly from a supplier in China, it's important to verify that all technical data sheets (TDS) and safety data sheets (SDS) are readily available and accurately reflect the product's properties. This diligence ensures that you are purchasing a reliable compound that meets your stringent requirements.

We are a trusted manufacturer and supplier offering high-quality 3-ethoxy-4-methoxybenzonitrile. If you are evaluating suppliers or looking to purchase this intermediate for your R&D or manufacturing needs, please contact us for detailed specifications, pricing, and quotation.