The world of chemical synthesis is constantly evolving, with new molecular structures emerging that unlock novel therapeutic and material possibilities. Among these, heterocyclic compounds featuring boron functionalities have gained significant traction due to their versatility in organic reactions. One such compound, tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate (CAS 877399-74-1), exemplifies the sophisticated building blocks that drive innovation in the pharmaceutical and chemical industries. As a dedicated manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. is at the forefront of providing these essential compounds.

Let's dissect the structure of this key intermediate. The name itself provides clues: 'tert-Butyl' refers to a bulky alkyl group, often used as a protecting group in organic synthesis, specifically attached to a 'piperidine-1-carboxylate' moiety. This forms a Boc-protected piperidine ring, a common structural element in many drug molecules. The 'pyrazol-1-yl' indicates a pyrazole ring, a five-membered heterocycle containing two adjacent nitrogen atoms, known for its pharmacological relevance. Finally, the '4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)' denotes a boronic acid pinacol ester group attached at the 4-position of the pyrazole ring. This boronic ester is the key functional group responsible for its reactivity in cross-coupling reactions.

The primary application driving the demand for this compound is its role as a critical intermediate in the synthesis of Crizotinib. Crizotinib is a targeted therapy approved for certain types of non-small cell lung cancer (NSCLC) that express specific genetic mutations (ALK or ROS1). The synthesis of such complex molecules requires precise chemical transformations, and this boronic ester intermediate plays a vital role in forming a crucial carbon-carbon bond within the Crizotinib structure.

Beyond its direct use in Crizotinib synthesis, tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate serves as a valuable tool for drug discovery chemists. Its robust structure and reactive boronic ester make it amenable to various Suzuki-Miyaura couplings, enabling the rapid synthesis of diverse libraries of related compounds. Researchers can explore structure-activity relationships (SAR) more efficiently, accelerating the identification of new drug candidates. For any organization looking to buy these advanced intermediates, partnering with a reliable pharmaceutical intermediate supplier like NINGBO INNO PHARMCHEM CO.,LTD. is essential for ensuring consistent quality and supply.

The availability of this compound in high purity (≥98%) from a trusted manufacturer in China ensures that R&D projects proceed smoothly without the complications of impure reagents. We offer competitive pricing and reliable delivery, making it easier for researchers and production teams to secure the materials they need. If you are involved in pharmaceutical development, drug discovery, or advanced organic synthesis, consider the strategic advantage of incorporating this versatile building block into your workflow. Contact us to obtain a quotation or discuss bulk purchasing options for tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate.