The chemical industry thrives on the precise synthesis and application of specialized compounds. Among these, pharmaceutical intermediates hold particular significance, enabling the creation of vital medicines. 1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride, identified by its CAS number 70918-74-0, is one such compound, primarily recognized for its role in the synthesis of Doxazosin. This article provides an overview of its synthesis, properties, and critical applications, highlighting its importance in the pharmaceutical sector.

Synthesis Pathways for 1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride

The production of 1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride typically involves a multi-step synthetic process. A common route begins with the reaction of piperazine with an activated derivative of 1,4-benzodioxane-2-carboxylic acid. This could involve using the corresponding acid chloride or activating the carboxylic acid with coupling reagents. The reaction aims to form an amide bond between the piperazine nitrogen and the benzodioxane carbonyl group.

Key starting materials often include:

  • Piperazine: A cyclic diamine that serves as a core structural component.
  • 1,4-Benzodioxane-2-carboxylic acid or its derivatives: This provides the benzodioxane moiety and the carbonyl group for amide formation. Ethyl 1,4-Benzodioxan-2-carboxylate is a frequently cited precursor.

The process generally involves careful control of reaction conditions, including temperature, solvent, and pH, to maximize yield and minimize side reactions. Following the reaction, purification steps are essential to isolate the desired product and remove unreacted starting materials or by-products. The hydrochloride salt is typically formed by treating the free base with hydrochloric acid, enhancing stability and handling properties. The final product is often a white to off-white crystalline solid.

Applications and Significance

The primary and most significant application of 1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride is its use as a key intermediate in the synthesis of Doxazosin mesylate. Doxazosin is a widely prescribed alpha-1 blocker used to treat conditions such as hypertension (high blood pressure) and benign prostatic hyperplasia (BPH). The structural integrity and purity of CAS 70918-74-0 are therefore critical for the successful and safe production of Doxazosin.

Beyond its direct role in Doxazosin synthesis, this compound may also be utilized in:

  • Research and Development: In medicinal chemistry laboratories exploring new drug candidates with similar structural motifs.
  • Impurity Standards: As a reference standard for quality control of Doxazosin API, as it can be a known related substance or impurity.

Sourcing High-Quality Intermediates

For pharmaceutical companies and research institutions, sourcing reliable suppliers for intermediates like CAS 70918-74-0 is vital. Manufacturers committed to high purity, robust synthesis processes, and stringent quality control ensure that the end drug product is safe and effective. As a trusted supplier, we offer 1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride with guaranteed specifications. Contact us today to learn more about our products and to secure a reliable supply chain for your synthesis needs.