NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing in-depth information on the chemical intermediates we supply, ensuring our clients have a thorough understanding of their properties and applications. 2-Amino-5-Fluoropyridine (CAS: 21717-96-4) is a prime example of a compound whose utility is deeply rooted in its synthesis and chemical characteristics.

The synthesis of 2-Amino-5-Fluoropyridine typically involves multi-step processes starting from readily available precursors. One common route begins with 2-aminopyridine, which undergoes a series of reactions including nitrification, acetylation of the amino group, reduction of the nitro group, diazotization, and finally, the Schiemann reaction to introduce the fluorine atom. Another approach might involve direct fluorination of pyridine derivatives. The efficiency and yield of these synthetic pathways are crucial for ensuring the cost-effectiveness and availability of high-purity 2-Amino-5-Fluoropyridine for industrial use. Manufacturers often focus on optimizing these routes to minimize side products and maximize the desired isomer.

The chemical properties of 2-Amino-5-Fluoropyridine are central to its function as a versatile intermediate. The molecule exhibits basic properties due to the pyridine nitrogen and the amino group. The fluorine atom at the 5-position acts as an electron-withdrawing group, influencing the electron density distribution across the pyridine ring. This electronic effect modulates the reactivity of both the ring and the amino substituent. For example, the amino group can readily participate in acylation, alkylation, and diazotization reactions, while the pyridine ring can undergo electrophilic or nucleophilic aromatic substitution depending on the reaction conditions and activating/deactivating groups present.

Understanding these chemical properties is vital for anyone looking to buy 2-Amino-5-Fluoropyridine. Its solubility in polar organic solvents like ethanol and DMSO, contrasted with its poor solubility in water, dictates appropriate reaction and purification conditions. The melting point, typically around 92-95°C, indicates its solid state at room temperature, making it easy to handle and store. For those engaging in complex organic synthesis, a thorough grasp of the CAS 21717-96-4 chemical properties ensures successful reaction design and execution.

At NINGBO INNO PHARMCHEM CO.,LTD., we ensure that our 2-Amino-5-Fluoropyridine meets rigorous purity standards, often exceeding 98% as determined by analytical methods like HPLC. This commitment to quality is fundamental to its successful application as a pharmaceutical intermediate, agrochemical building block, and in other specialized chemical syntheses.