For chemists engaged in organic synthesis and pharmaceutical development, a deep understanding of their chemical building blocks is crucial. 8-Bromo-2H-Isoquinolin-1-one (CAS 475994-60-6) is a fine chemical intermediate that offers unique structural characteristics, making it a valuable component in various synthetic strategies. This article explores the typical synthesis pathways and the key chemical properties of this compound, highlighting its significance for researchers and procurement specialists.

The synthesis of 8-Bromo-2H-Isoquinolin-1-one commonly involves established organic reactions. One reported method includes the bromination of the isoquinolinone system. For instance, starting from 8-bromoisoquinoline 2-oxide, treatment with trifluoroacetic anhydride in DMF, followed by neutralization and extraction, can yield the desired product. Purification via silica gel column chromatography ensures the high purity required for its applications. Understanding these synthesis routes is important for manufacturers to optimize production and for buyers to appreciate the effort involved in achieving product quality. This attention to detail in manufacturing is what distinguishes a reliable supplier.

Chemically, 8-Bromo-2H-Isoquinolin-1-one is characterized by its molecular formula C9H6BrNO and a molecular weight of approximately 224.05 g/mol. Its appearance is typically a white to off-white solid. Key physical properties, such as a melting point typically in the range of 181-183 °C and a boiling point of around 446.078 °C at 760 mmHg, provide essential data for handling and reaction planning. The density is approximately 1.62 g/cm³, indicating a relatively dense solid. These parameters are critical for formulators and scientists when designing reactions or when considering its use in specific formulations.

Safety considerations are also paramount when dealing with such compounds. Hazard statements often include warnings for ingestion, skin contact, eye irritation, and respiratory tract irritation, necessitating the use of appropriate personal protective equipment (PPE) such as gloves, safety glasses, and respiratory protection. Proper storage conditions, typically in a cool, dry place away from incompatible materials, are essential to maintain product integrity and safety. A responsible manufacturer will always provide comprehensive safety data sheets (SDS) to guide safe handling and storage practices.

For professionals looking to buy 8-Bromo-2H-Isoquinolin-1-one, grasping these synthetic and property details ensures informed purchasing decisions. Knowing the synthesis pathways helps in verifying the product's origin and potential impurities, while understanding its properties aids in its effective application. Partnering with manufacturers who clearly communicate these aspects builds trust and facilitates successful outcomes in research and production. When you need a reliable source for this chemical intermediate, consider a dedicated manufacturer who prioritizes detailed technical information and consistent quality.