In the complex world of chemical synthesis, understanding the properties and production methods of key intermediates is fundamental for innovation. 5-Benzyl L-glutamate N-carboxyanhydride (CAS: 3190-71-4), often referred to as Benzyl Glutamate NCA, is one such compound that plays a vital role in the creation of advanced materials and pharmaceutical precursors.

As a derivative of L-glutamic acid, its structure features an N-carboxyanhydride (NCA) ring, which is highly reactive and prone to ring-opening polymerization. This characteristic makes it an excellent monomer for the synthesis of polypeptides, leading to materials with potential applications in biomedicine, such as biodegradable polymers and drug delivery systems. The benzyl ester group serves as a protecting group, influencing the molecule's solubility and reactivity, and can be selectively removed later in synthesis.

The synthesis of benzyl glutamate NCA typically involves reacting the protected amino acid with reagents like phosgene or triphosgene under controlled anhydrous conditions. For instance, a common method involves dissolving gamma-benzyl-L-glutamate in tetrahydrofuran (THF), followed by the addition of triphosgene at elevated temperatures. The resulting NCA is then precipitated and purified. Achieving high purity, often above 95%, is crucial for its effective use in sensitive polymerization reactions.

For researchers and industrial clients, sourcing high-quality benzyl glutamate NCA from a reliable 5-Benzyl L-glutamate N-carboxyanhydride manufacturer is paramount. NINGBO INNO PHARMCHEM CO.,LTD., as a premier 5-Benzyl L-glutamate N-carboxyanhydride supplier in China, is dedicated to providing materials that meet these stringent requirements. When you choose to buy CAS 3190-71-4 from us, you are assured of product integrity and consistent quality, which are critical for successful research and development.

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