For chemists and R&D professionals, a deep understanding of the synthesis and properties of chemical intermediates is fundamental to successful product development. (3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione, identified by its CAS number 14805-29-9, is a prime example of such a compound, with significant utility in the pharmaceutical sector, notably in the synthesis of Lurasidone.

The synthesis of (3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione often involves a multi-step process starting from readily available precursors. One common approach detailed in chemical literature and patents describes the hydrogenation of a precursor molecule, such as a related anhydride or imide, under specific catalytic conditions. For instance, a described synthesis involves using activated carbon as a catalyst in a methanol solvent, followed by rigorous purification steps to achieve the desired stereochemistry and high purity. The careful control of reaction parameters, including pressure, temperature, and catalyst loading, is critical to maximizing yield and minimizing by-products.

Regarding its properties, CAS 14805-29-9 typically presents as a white to off-white crystalline powder. Key physical properties such as melting point (often cited around 152°C or 173-176°C depending on the source and purity), density, and solubility in various organic solvents are important for handling and reaction planning. Its stability under standard storage conditions (often recommended at 2-8°C) is also a crucial factor for maintaining its quality over time. Researchers often look for detailed technical data sheets provided by manufacturers when evaluating this intermediate for their synthesis projects.

The chemical reactivity of the imide functional group within (3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione makes it a versatile building block. It readily participates in reactions such as N-alkylation or condensation, allowing for the introduction of diverse substituents. This inherent versatility is what makes it so valuable in the complex multi-step synthesis of active pharmaceutical ingredients (APIs). Anyone looking to purchase this intermediate should confirm its exact specifications and available purity grades to match their laboratory or production needs.

Understanding these synthetic routes and inherent properties allows chemists to effectively incorporate CAS 14805-29-9 into their workflows. As a leading manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing detailed product information and ensuring the consistent quality of this important fine chemical.