For professionals in chemical R&D and manufacturing, understanding the synthesis and quality control of essential intermediates like 2-Amino-5-bromo-3-nitropyridine (CAS 6945-68-2) is fundamental to ensuring product integrity and process efficiency. This compound's specific structure and reactivity make it a vital component in many advanced chemical syntheses.

The synthesis of 2-Amino-5-bromo-3-nitropyridine typically commences with 2-amino-5-bromopyridine. The critical step involves electrophilic nitration, usually achieved using a mixture of concentrated sulfuric acid and concentrated nitric acid. Maintaining strict temperature control, typically between 0-5°C, during the addition of nitric acid is paramount. This precise temperature management is key to directing the nitro group to the desired position on the pyridine ring and minimizing the formation of undesired byproducts or decomposition. Following the nitration, careful work-up, including neutralization and precipitation, is performed to isolate the crude product.

Quality control for 2-Amino-5-bromo-3-nitropyridine is rigorous, especially when intended for pharmaceutical or high-purity chemical applications. The primary metrics include assay purity, typically measured by High-Performance Liquid Chromatography (HPLC), with target levels often exceeding 98.0%. Manufacturers also monitor physical properties such as appearance (typically a yellow to light-brown powder) and melting point (around 205-208°C). Checking for trace impurities that could interfere with downstream reactions is also a critical part of the quality assurance process.

For those looking to buy 2-amino-5-bromo-3-nitropyridine, it is essential to partner with manufacturers who employ robust quality management systems. Requesting detailed documentation, including Certificates of Analysis (COA) and Safety Data Sheets (SDS), is standard practice. These documents provide critical information about the batch's purity, physical and chemical properties, and safe handling procedures. Reliable 2-amino-5-bromo-3-nitropyridine suppliers will ensure this information is readily available.

The price of 2-Amino-5-bromo-3-nitropyridine can vary depending on purity, order volume, and supplier. However, investing in a high-quality product from a reputable 2-amino-5-bromo-3-nitropyridine manufacturer often proves more cost-effective in the long run by preventing synthesis failures or product deviations. Understanding the CAS 6945-68-2 synthesis route employed by a supplier can also provide insights into their production capabilities and commitment to quality.

In essence, the successful utilization of 2-Amino-5-bromo-3-nitropyridine in various industries is underpinned by a thorough understanding of its synthesis and stringent quality control. By selecting qualified suppliers who prioritize product integrity, researchers and manufacturers can confidently integrate this vital intermediate into their chemical processes, driving innovation and ensuring the reliability of their end products.