Efavirenz, a cornerstone medication in the treatment of HIV/AIDS, relies on a complex and carefully orchestrated synthetic process. Central to this process is the use of specific chemical intermediates, among which 1,1-Ethanediol, 1-(2-amino-5-chlorophenyl)-2,2,2-trifluoro-, hydrochloride (1:1), identified by CAS 214353-17-0, plays a pivotal role. Understanding the significance of this intermediate is key for manufacturers aiming for efficient and cost-effective Efavirenz production.

The synthesis of Efavirenz typically involves several key steps, each requiring precisely formulated chemical precursors. CAS 214353-17-0, a trifluoroacetophenone hydrochloride derivative, serves as one of the primary building blocks. Its structure, featuring the critical trifluoromethyl group and a chlorinated phenyl amine moiety, is instrumental in forming the core heterocyclic structure of Efavirenz. The high purity (often 99%) of this intermediate is non-negotiable, as any impurities can lead to side reactions, reduced yields, and the formation of unwanted by-products that are difficult and costly to remove from the final API.

For pharmaceutical manufacturers, the consistent and reliable supply of CAS 214353-17-0 is a critical operational factor. Procurement teams actively seek out manufacturers and suppliers who can guarantee both quality and volume. Searches like “Efavirenz intermediate for sale” or “buy CAS 214353-17-0 in bulk” are common, reflecting the direct commercial intent of these buyers. China has emerged as a leading global supplier of such pharmaceutical intermediates, offering competitive pricing and large-scale production capabilities. Companies that can provide comprehensive documentation, such as CoAs and regulatory support, are highly preferred.

The chemical properties of CAS 214353-17-0, including its appearance as a white to off-white crystalline powder, are also important for handling and integration into manufacturing processes. Its stability and reactivity under specific reaction conditions are well-studied, allowing for optimized synthetic protocols. NINGBO INNO PHARMCHEM CO.,LTD., as a dedicated manufacturer and supplier of fine chemicals and pharmaceutical intermediates, understands the stringent requirements for Efavirenz synthesis. By focusing on quality control and robust supply chain management, they aim to provide pharmaceutical manufacturers with a dependable source for this essential intermediate.

In summary, the role of CAS 214353-17-0 in Efavirenz synthesis cannot be overstated. It is more than just a chemical; it is a vital component that enables the production of a life-saving drug. For any manufacturer involved in Efavirenz production, securing a stable supply of high-purity CAS 214353-17-0 from a trusted supplier is a strategic imperative.