In the realm of fine chemicals, certain compounds stand out for their versatility and critical role in enabling advanced manufacturing processes. Trifluoro-p-tolunitrile, identified by its CAS number 455-18-5, is one such compound. This article provides a comprehensive overview of its chemical properties, synthesis, and its significant industrial impact, particularly within the pharmaceutical and chemical sectors.

Trifluoro-p-tolunitrile, with the molecular formula C8H4F3N, is characterized by a benzene ring substituted with a nitrile group (-CN) and a trifluoromethyl group (-CF3) at the para position. This specific arrangement of functional groups endows the molecule with unique reactivity and physical properties. It typically presents as a white to light yellow crystalline powder, with a melting point often cited in the range of 39-41 °C. Its boiling point is around 80-81 °C at 20 mm Hg, indicating a moderate volatility. The compound is generally insoluble in water but soluble in common organic solvents like chloroform and methanol.

The trifluoro-p-tolunitrile synthesis often involves fluorination reactions and the introduction of the nitrile group onto a precursor molecule. While specific proprietary methods vary among manufacturers, the general aim is to achieve high purity and yield. Understanding these synthesis routes is important for identifying potential impurities and ensuring the suitability of the product for specific applications. The availability of reliable trifluoro-p-tolunitrile suppliers China ensures that these manufacturing capabilities are accessible globally.

Industrially, Trifluoro-p-tolunitrile's primary significance lies in its role as a key intermediate. In the pharmaceutical industry, it is a vital component in the synthesis of numerous active pharmaceutical ingredients (APIs). Its use as a fluvoxamine intermediate synthesis is well-documented, showcasing its importance in producing essential medications. The compound's ability to introduce the trifluoromethyl moiety is highly valued, as this group can significantly influence a drug molecule's lipophilicity, metabolic stability, and receptor binding affinity.

Beyond pharmaceuticals, Trifluoro-p-tolunitrile serves as a versatile building block for a wide array of organic synthetic raw materials. It is employed in the creation of agrochemicals, dyes, and specialty materials, where its unique chemical properties are leveraged to achieve desired performance characteristics. For businesses looking to buy 455-18-5 online, ensuring the product meets the stringent requirements for these diverse industrial applications is paramount. The uses of 4-(trifluoromethyl)benzonitrile are continuously being explored, promising further integration into new and innovative products.

In summary, Trifluoro-p-tolunitrile (CAS 455-18-5) is a fundamentally important fine chemical intermediate. Its distinct chemical properties, coupled with its critical roles in pharmaceutical synthesis and broader organic chemistry, underscore its industrial significance and ensure its continued demand across various high-tech sectors.

By NINGBO INNO PHARMCHEM CO., LTD.