Trimethyl Orthoformate (CAS: 149-73-5), also known by synonyms such as Methyl Orthoformate or Trimethoxymethane, is a compound of significant industrial and synthetic importance. Understanding its chemical properties, synthesis routes, and safe handling practices is crucial for professionals in the chemical and pharmaceutical sectors. As a dedicated manufacturer of fine chemicals in China, NINGBO INNO PHARMCHEM CO.,LTD. aims to provide comprehensive information on this versatile reagent.

Chemically, Trimethyl Orthoformate is an acetal with the molecular formula C4H10O3 and a molecular weight of 106.12 g/mol. It presents as a colorless, transparent liquid with a characteristic pungent odor. Its high flammability, indicated by a low flash point of around 13°C, necessitates careful handling and storage. While soluble in common organic solvents like ether and alcohol, it is sensitive to moisture and hydrolyzes in water, which is an important consideration during its application and storage. Its chemical structure, HC(OCH3)3, is the basis for its reactivity in various organic transformations.

The industrial synthesis of Trimethyl Orthoformate typically involves the methanolysis of hydrogen cyanide. This method, represented by the reaction HCN + 3 HOCH3 → HC(OCH3)3 + NH3, is an efficient and scalable process suitable for large-scale production. Another method involves the reaction of chloroform with sodium methoxide. Both pathways are well-established and utilized by manufacturers to ensure a consistent supply of high-purity product. Our manufacturing capabilities leverage these optimized synthesis routes.

Safety is a paramount concern when dealing with Trimethyl Orthoformate. Due to its high flammability, it must be kept away from heat, sparks, and open flames. It is also an irritant to the skin and eyes, and inhalation of vapors should be avoided by ensuring adequate ventilation. Proper storage in tightly sealed containers, in a dry and well-ventilated area, away from oxidizing agents and acids, is essential to prevent hazardous reactions. Adherence to Safety Data Sheet (SDS) guidelines is strongly recommended for all users.

For businesses requiring a reliable supplier of Trimethyl Orthoformate, NINGBO INNO PHARMCHEM CO.,LTD. offers high-quality material backed by expertise in chemical manufacturing. We are committed to providing safe and efficient solutions for your procurement needs. Whether for pharmaceutical synthesis, agrochemical production, or other industrial applications, trust us to deliver on quality and safety.