Voriconazole, identified by its CAS number 137234-62-9, is a vital pharmaceutical intermediate and a potent broad-spectrum antifungal agent. Its significance in treating serious fungal infections makes it a highly sought-after compound for pharmaceutical manufacturers and drug developers worldwide. For B2B buyers, understanding the chemical characteristics and primary applications of Voriconazole is crucial for strategic sourcing and effective utilization. This overview details what makes Voriconazole a cornerstone in antifungal therapy.

Chemical Profile and Mechanism of Action

Voriconazole is a triazole derivative characterized by its complex molecular structure, which includes fluorine atoms and a pyrimidine ring. Its molecular formula is C16H14F3N5O, and its molecular weight is approximately 349.31 g/mol. The compound functions by inhibiting the fungal cytochrome P450 enzyme, specifically lanosterol 14α-demethylase. This enzyme is essential for the synthesis of ergosterol, a critical component of the fungal cell membrane. By disrupting ergosterol synthesis, Voriconazole destabilizes the fungal cell membrane, leading to cell death.

This mechanism provides Voriconazole with its broad-spectrum activity against a range of pathogenic fungi, including species of Candida, Aspergillus, and others. Its efficacy against invasive infections makes it a critical therapeutic option.

Key Applications in the Pharmaceutical Industry

The primary role of Voriconazole in the pharmaceutical industry is as an active ingredient or a critical intermediate in the production of antifungal medications. Its key applications include:

  • Treatment of Invasive Fungal Infections: It is a life-saving drug for patients suffering from serious infections like invasive aspergillosis, candidemia, and others, particularly those with compromised immune systems.
  • Formulation of Dosage Forms: Pharmaceutical companies utilize Voriconazole to develop various dosage forms, including oral tablets and intravenous solutions.
  • Drug Development and Research: It serves as a reference standard and research chemical for developing new antifungal therapies and understanding fungal resistance mechanisms.

Sourcing Voriconazole: A Manufacturer's Perspective

For pharmaceutical companies looking to buy Voriconazole, partnering with a reputable manufacturer that guarantees high purity (often above 98%) is essential. Consistent batch-to-batch quality, reliable supply, and competitive pricing are key considerations. Manufacturers often work to optimize synthesis routes to ensure both product quality and cost-effectiveness. Understanding the CAS number 137234-62-9 ensures that you are procuring the correct compound for your specific pharmaceutical needs.

As a dedicated manufacturer and supplier, we are committed to providing the pharmaceutical industry with high-quality Voriconazole. Our advanced synthesis capabilities and stringent quality control measures ensure that our product meets the exacting standards required for pharmaceutical applications. If you are seeking a reliable source to buy Voriconazole or require a quote for bulk quantities, please contact our sales team. We are equipped to support your manufacturing and R&D objectives.