For chemists and material scientists, having access to versatile and reactive building blocks is fundamental to unlocking new possibilities in synthesis. 1-Chloro-3-iodobenzene (CAS: 625-99-0) is precisely such a compound, offering a unique combination of halogen functionalities on an aromatic core. As a proactive manufacturer and supplier, we provide this essential chemical to fuel innovation across industries, particularly in the development of OLED materials and pharmaceuticals. If you are looking to buy this compound, understanding its synthetic utility is key.

The Synthetic Versatility of 1-Chloro-3-iodobenzene

1-Chloro-3-iodobenzene is prized for its dual reactivity. The iodine atom is an excellent leaving group, readily participating in a wide range of transition-metal-catalyzed cross-coupling reactions. These include:

  • Suzuki Coupling: Reacting with boronic acids or esters to form new carbon-carbon bonds.
  • Stille Coupling: Coupling with organotin reagents.
  • Heck Reaction: Reacting with alkenes to form substituted alkenes.
  • Sonogashira Coupling: Coupling with terminal alkynes to create alkynylated aromatics.
  • Buchwald-Hartwig Amination: Forming carbon-nitrogen bonds by reacting with amines.

The chlorine atom, while generally less reactive than iodine in these coupling reactions, can be selectively addressed under different catalytic conditions or serve as a persistent functional group that influences the electronic properties of the final molecule. This differential reactivity allows for sequential functionalization, making 1-Chloro-3-iodobenzene a highly strategic building block for constructing complex organic molecules.

Applications Driving Demand

The demand for high-purity 1-Chloro-3-iodobenzene is largely driven by its critical roles:

  • OLED Intermediates: In the field of optoelectronics, this compound is integral to synthesizing host materials, charge transport layers, and emissive compounds for OLED displays and lighting. Its structure contributes to desirable electronic and photophysical properties in the final OLED materials.
  • Pharmaceutical Intermediates: As a vital pharmaceutical intermediate, it is used in the synthesis of various APIs. Its ability to introduce specific functional groups and build complex scaffolds makes it invaluable in drug discovery and development.
  • Fine Chemical Synthesis: Beyond these major areas, it serves as a general reagent in fine chemical synthesis for creating specialized organic compounds with targeted properties.

For researchers aiming to optimize their synthesis pathways or develop novel materials, sourcing high-quality 1-Chloro-3-iodobenzene is essential. When you decide to buy this chemical, understanding these applications will help you communicate your needs effectively to a supplier.

Efficient Sourcing Strategies

To ensure you obtain the best quality and value for 1-Chloro-3-iodobenzene, consider these sourcing tips:

  • Prioritize Purity: Always look for suppliers who guarantee high purity (e.g., ≥97% or ≥99%) and provide detailed Certificates of Analysis (CoA).
  • Engage with Manufacturers: Directly contacting a manufacturer, especially one based in China, can often yield better pricing and more direct technical support.
  • Request Free Samples: To confirm suitability for your specific reactions, always request a free sample before placing a bulk order.
  • Compare Quotes: Obtain multiple quotes to ensure you are getting a competitive price for the quality you require.

Conclusion

1-Chloro-3-iodobenzene is a powerful tool in the modern synthetic chemist's arsenal, enabling advancements in OLED technology and pharmaceutical development. By partnering with a reliable manufacturer and supplier, you can ensure consistent access to this high-quality intermediate, empowering your research and production goals. We are committed to supporting your synthetic endeavors by providing this essential building block. Contact us today to discuss your requirements and secure your supply.