In the dynamic field of biochemical research and pharmaceutical development, the precise synthesis of peptides is paramount. Among the crucial reagents enabling these advancements is Fmoc-D-3-Methylphenylalanine (CAS 352351-64-5). This Fmoc-protected amino acid serves as a vital building block, offering unique advantages for researchers and chemists aiming to create novel peptide sequences with specific functionalities.

Fmoc-D-3-Methylphenylalanine stands out due to its Fmoc (9-fluorenylmethyloxycarbonyl) protecting group. This group is widely favored in solid-phase peptide synthesis for its stability under coupling conditions and its facile removal under mild basic conditions. This selective deprotection strategy is key to the stepwise elongation of peptide chains, allowing for the accurate incorporation of each amino acid. The ‘D’ configuration indicates the specific stereochemistry, which can be crucial for biological activity and peptide folding.

What further distinguishes this compound is the presence of a methyl group attached to the meta position of the phenylalanine side chain. This structural modification is not merely cosmetic; it can significantly influence the physicochemical properties of the resulting peptide. By altering the steric and electronic environment around the amino acid residue, the methyl group can affect peptide conformation, solubility, and interactions with biological targets like receptors or enzymes. This makes Fmoc-D-3-Methylphenylalanine an invaluable tool for structure-activity relationship (SAR) studies, a fundamental aspect of drug discovery. Researchers can strategically incorporate this modified amino acid to fine-tune a peptide’s therapeutic profile, potentially leading to enhanced efficacy or reduced side effects.

As a sought-after specialty chemical, Fmoc-D-3-Methylphenylalanine is available from various suppliers, with many reputable manufacturers and suppliers located in China. These suppliers often provide high-purity grades, ensuring that the material meets the stringent requirements of peptide synthesis and research applications. When sourcing this compound, looking for a reliable supplier that offers detailed specifications and consistent quality is essential. For those looking to buy this critical reagent, understanding its CAS number (352351-64-5) is key to identifying the correct product from various online chemical marketplaces and specialized distributors.

The application of Fmoc-D-3-Methylphenylalanine extends beyond basic research. It plays a critical role in the development of peptide-based therapeutics, diagnostics, and biochemical probes. Its ability to introduce subtle yet significant changes in peptide structure makes it a cornerstone for custom peptide synthesis projects. By providing researchers with access to such specialized building blocks, chemical suppliers facilitate groundbreaking work in areas ranging from medicinal chemistry to material science. The ongoing demand for novel peptide sequences with tailored properties ensures that compounds like Fmoc-D-3-Methylphenylalanine will continue to be indispensable tools for scientific innovation.

In conclusion, Fmoc-D-3-Methylphenylalanine is more than just a chemical reagent; it is an enabler of advanced peptide design and discovery. Its specific properties, coupled with the efficiency of Fmoc chemistry, empower researchers to push the boundaries of what is possible in peptide science. Whether you are optimizing a peptide therapeutic or exploring fundamental biological mechanisms, this compound offers a reliable path to achieving your scientific goals.