The field of peptide synthesis is a cornerstone of modern pharmaceutical research and development. At the heart of successful peptide synthesis lies the quality and reliability of the amino acid derivatives used. Among these, Fmoc-D-Cys(Trt)-OH, bearing the CAS number 167015-11-4, stands out as a crucial component for many researchers and manufacturers. This article delves into why this particular derivative is so important and how to source it effectively.

Fmoc-D-Cys(Trt)-OH, also known as Fmoc-S-trityl-D-cysteine, is a protected form of the amino acid D-cysteine. The 'Fmoc' (9-fluorenylmethoxycarbonyl) group serves as a base-labile protecting group for the alpha-amino group, essential for sequential addition of amino acids in peptide chains without unwanted side reactions. The 'Trt' (trityl) group is a protecting group for the thiol side chain of cysteine. Cysteine's thiol group is highly reactive and crucial for forming disulfide bonds, which are vital for the three-dimensional structure of many proteins and peptides. By protecting this thiol group, the trityl moiety ensures that the disulfide bond formation occurs only at the desired stage of synthesis, allowing for precise control over protein folding and function.

The 'D' in Fmoc-D-Cys(Trt)-OH indicates that it is the D-enantiomer of cysteine, rather than the more common L-enantiomer. While L-amino acids are the building blocks of proteins found in nature, D-amino acids are increasingly recognized for their utility in creating peptides with enhanced stability against enzymatic degradation. This increased resistance makes D-amino acid-containing peptides attractive candidates for therapeutic applications, as they can have longer half-lives in the body.

The physical form of Fmoc-D-Cys(Trt)-OH is typically a white powder. This physical characteristic is common for many amino acid derivatives used in solid-phase peptide synthesis (SPPS). The purity of the material is paramount; for researchers and manufacturers aiming for high-quality peptide products, sourcing a supplier that guarantees high purity, often 98% or above, is critical. This ensures that the synthesized peptide is free from impurities that could affect its biological activity or lead to incorrect structural formation.

For procurement managers and R&D scientists looking to buy Fmoc-D-Cys(Trt)-OH, understanding the supply landscape is key. China has emerged as a significant global manufacturer and supplier of specialty chemicals, including amino acid derivatives. Partnering with a reputable Chinese manufacturer can offer competitive pricing and reliable supply. When searching for a manufacturer, keywords like 'Fmoc-D-Cys(Trt)-OH supplier China', 'CAS 167015-11-4 price', or 'buy protected amino acids' are effective. It is always advisable to request a Certificate of Analysis (CoA) to verify purity and other specifications. Working with a dedicated supplier ensures that you receive a consistent product for your peptide synthesis needs.

In summary, Fmoc-D-Cys(Trt)-OH (CAS 167015-11-4) is an indispensable reagent for advanced peptide synthesis, particularly when resistance to degradation or specific structural features are desired. Its availability as a high-purity white powder from reliable manufacturers and suppliers, especially those in China, makes it an accessible and valuable tool for innovation in drug discovery and biochemical research.