The landscape of chemical synthesis is constantly evolving, driven by the need for novel compounds with enhanced properties. In this quest, specialized intermediates play a pivotal role. 1,1-Dibromo-3,3,3-trifluoroacetone (CAS 431-67-4) stands out as a versatile and reactive building block, essential for many advanced organic chemistry applications.

Chemical Properties and Reactivity

1,1-Dibromo-3,3,3-trifluoroacetone is characterized by its light-orange liquid appearance and a molecular formula of C3HBr2F3O. Its reactivity stems from the electron-withdrawing trifluoromethyl group and the two labile bromine atoms, making it an excellent electrophile. This property allows it to readily participate in various synthetic transformations.

Applications in Pharmaceutical and Agrochemical Industries

One of the most significant applications for this compound is in the pharmaceutical sector. It serves as a critical intermediate for the synthesis of 3,4-disubstituted pyrazole analogues, which are investigated as potential anti-tumor CDK inhibitors. Researchers also employ it in the synthesis of trifluoromethyl heterocycles, compounds that often exhibit enhanced metabolic stability and efficacy in drug candidates. Beyond pharmaceuticals, its utility extends to the agrochemical industry, where it can be used in the preparation of pyridazinone derivatives, valuable as herbicide intermediates.

Procurement and Availability: Finding the Right Supplier

For procurement managers seeking to buy 1,1-Dibromo-3,3,3-trifluoroacetone, it is essential to partner with reputable manufacturers and suppliers. Identifying a reliable chemical supplier in China that offers high-purity grades (e.g., 98% or higher) is key to ensuring successful synthesis outcomes. When searching for 'CAS 431-67-4 price' or 'pharmaceutical intermediate manufacturer', evaluating suppliers based on quality control, production capacity, and customer service is recommended. A well-established supplier can provide the necessary documentation, such as Certificates of Analysis, and offer competitive pricing for bulk orders.

Handling and Safety

As with many reactive organic compounds, proper handling and safety precautions are necessary when working with 1,1-Dibromo-3,3,3-trifluoroacetone. Users should consult the Material Safety Data Sheet (MSDS) for detailed information on hazards, personal protective equipment (PPE), and storage recommendations. Storing it under an inert atmosphere at 2-8°C is often advised to maintain its stability.

In conclusion, 1,1-Dibromo-3,3,3-trifluoroacetone is a powerful tool for chemists engaged in cutting-edge research. Whether you are developing new cancer therapies or innovative agrochemicals, securing a dependable supply of this intermediate is a crucial step. Consider us your trusted source for this vital chemical, providing consistent quality and reliable service.