For researchers engaged in organic synthesis and drug discovery, understanding the practical application and handling of key intermediates like 2-Nitrobenzenethiol (CAS 4875-10-9) is paramount. As a versatile building block, its unique chemical structure allows for a range of reactions, but successful implementation requires careful consideration of reaction conditions and material sourcing. This article provides insights into utilizing 2-Nitrobenzenethiol effectively in your research and development projects.

Understanding the Reactivity of 2-Nitrobenzenethiol

2-Nitrobenzenethiol possesses both a thiol (-SH) group and a nitro (-NO2) group attached to a benzene ring. The thiol group is acidic and nucleophilic, making it susceptible to oxidation and alkylation. The nitro group is an electron-withdrawing group that can influence the reactivity of the aromatic ring and can also be reduced to an amino group under appropriate conditions. When planning a synthesis using 2-Nitrobenzenethiol, researchers should consider these reactive functionalities. For instance, protecting the thiol group might be necessary in certain reactions to prevent undesired side products or self-oxidation.

Optimizing Synthesis Conditions for CAS 4875-10-9

When you buy 2-Nitrobenzenethiol online from a reputable chemical manufacturer like NINGBO INNO PHARMCHEM CO.,LTD., you receive a product with guaranteed purity (≥99%), which is crucial for predictable reaction outcomes. Common reactions involving 2-Nitrobenzenethiol include:

  • Alkylation: The thiol group readily reacts with alkyl halides or other electrophiles in the presence of a base to form thioethers.
  • Oxidation: Mild oxidation can lead to disulfides, while stronger oxidants can yield sulfonic acids.
  • Reduction of Nitro Group: The nitro group can be reduced to an amino group (forming 2-aminobenzenethiol) using various reducing agents like catalytic hydrogenation, tin/HCl, or iron/acetic acid.

It is essential to control reaction temperature, solvent choice, and reagent stoichiometry to achieve optimal yields and selectivity. Always consult the Safety Data Sheet (SDS) provided by the supplier for proper handling and storage procedures. Proper ventilation and personal protective equipment are vital when working with thiols.

Sourcing High-Quality Intermediates

For your R&D to proceed smoothly, securing a reliable source of 2-Nitrothiophenol is key. As a trusted supplier in China, NINGBO INNO PHARMCHEM CO.,LTD. offers high-purity 2-Nitrobenzenethiol (CAS 4875-10-9) that meets stringent quality standards. We understand the importance of consistent material for research. We invite you to contact us to learn more about our products and how we can support your synthesis projects with dependable materials and competitive pricing.