For research and development scientists in the pharmaceutical sector, the selection of appropriate chemical intermediates is a critical step in the drug discovery and development process. 3,5-Dichloroiodobenzene (CAS: 3032-81-3) represents a valuable reagent, offering unique structural features that facilitate the synthesis of complex Active Pharmaceutical Ingredients (APIs). Understanding its reactivity and sourcing it from a dependable manufacturer are key to successful pharmaceutical synthesis.

The chemical structure of 3,5-Dichloroiodobenzene, characterized by a benzene ring substituted with two chlorine atoms and one iodine atom, makes it a highly versatile building block. The iodine atom, being a good leaving group, is particularly amenable to various transition-metal catalyzed cross-coupling reactions. This includes palladium-catalyzed couplings like Suzuki-Miyaura, Heck, Sonogashira, and Buchwald-Hartwig aminations, all of which are workhorse reactions in modern medicinal chemistry for forming carbon-carbon and carbon-heteroatom bonds. These reactions allow for the precise introduction of diverse functional groups, enabling the construction of complex molecular scaffolds essential for biological activity.

Scientists often seek to buy 3,5-Dichloroiodobenzene that offers high purity (typically 97% or higher) to ensure reproducible results and minimize the formation of unwanted byproducts. The physical properties, such as its appearance as a yellow powder and a melting point around 56-58 °C, are also important considerations for handling and reaction optimization. When planning synthetic routes, consider that the chlorine substituents on the ring can also influence reactivity and regioselectivity in subsequent transformations, offering additional design flexibility.

As a crucial pharmaceutical intermediate, the reliable supply of 3,5-Dichloroiodobenzene is vital. Partnering with a trusted manufacturer or supplier, particularly those based in China with established expertise in fine chemical production, can provide a stable source for this essential compound. Evaluating suppliers based on their product quality, batch-to-batch consistency, technical support, and pricing is a wise investment. By securing a dependable supply chain, R&D teams can accelerate their drug development timelines, confidently synthesizing novel therapeutics. If your research requires this intermediate, inquire about our manufacturing capabilities and obtain a quote to ensure you are sourcing from a premier supplier.